Results 41 to 50 of about 13,090 (254)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Freqüência das infecções pelo HIV-1, rubéola, sífilis, toxoplasmose, citomegalovírus, herpes simples, hepatite B, hepatite C, doença de Chagas e HTLV I/II em gestantes, do Estado de Mato Grosso do Sul Frequency of HIV-1, rubella, syphilis, toxoplasmosis, cytomegalovirus, simple herpes virus, hepatitis B, hepatitis C, Chagas’ disease and HTLV I/II infection in pregnant women of State of Mato Grosso do Sul

Revista da Sociedade Brasileira de Medicina Tropical, 2007
Objetivou-se avaliar a freqüência das infecções por sífilis, rubéola, hepatite B, hepatite C, toxoplasmose, doença de Chagas, HTLV I/II, herpes simples, HIV-1 e citomegalovírus em gestantes e relacionar a faixa etária das pacientes com a freqüência das ...
Ernesto Antonio Figueiró-Filho, Flávio Renato de Almeida Senefonte, Alessandro Henrique Antunes Lopes, Orlando Oliveira de Morais, Virgílio Gonçalves Souza Júnior, Tamara Lemos Maia, Geraldo Duarte   +6 more
doaj   +1 more source

Amniotic membrane in the treatment of corneal and scleral thinning [PDF]

, 2003
PURPOSE: To evaluate the use of amniotic membrane (AM) as an adjunct to the treatment of corneal and scleral thinnings. METHODS: Amniotic membrane was obtained at the time of cesarean section and was preserved at -80ºC in glycerol and cornea culture ...
Attie, Greicie Cristina Guerra, Fairbanks, Daniella, Freitas, Denise de, Gomes, José Álvaro Pereira, Santos, Walner Daros dos, Vieira, Luiz Antônio   +5 more
core   +3 more sources

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Herpes hipertrófico perianal tratado eficazmente com imiquimod Hypertrophic perianal herpes successfully treated with imiquimod

Anais Brasileiros de Dermatologia, 2011
A infecção pelo vírus herpes simples tipo 2 (HSV-2) é frequente em pacientes infetados pelo vírus de imunodeficiência adquirida (VIH). Nestes casos, o herpes genital pode ter uma apresentação clínica atípica.
Sara Isabel Alcântara Lestre, Alexandre João, Célia Carvalho, Vasco Vieira Serrão   +3 more
doaj   +1 more source

ÚLCERAS GENITAIS RECORRENTES EM PACIENTE PREVIAMENTE HÍGIDA: RELATO DE CASO

Brazilian Journal of Infectious Diseases, 2022
Introdução: A doença de Behçet é uma vasculite inflamatória sistêmica, de etiologia desconhecida, que se manifesta através de úlceras orais e genitais recorrentes e inflamações oculares podendo afetar todos os sistemas do corpo. É uma patologia rara, sem
Herbert José Fernandes, Rafaela Maria Saliba Ribeiro, Luísa Fernandes Ramos, Clara dos Reis Aguiar, Fernanda Sandrelly da Silva, Sâmia Silva Tanure, Luisa Paschoal Prudente, Gabriela Pacheco de Assis, Karolayne Joyce Oliveira   +8 more
doaj   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Study of the ocular findings in Stevens-Johnson syndrome patients from a tertiary ophthalmologic center [PDF]

, 2009
PURPOSE: To evaluate the epidemiology, possible etiologic factors, complications and treatment of a group of patients with ocular complications secondary to Stevens-Johnson syndrome.
Cunha, Marcelo, Franca, Marciel Dourado, Freitas, Denise de, Gomes, José Álvaro Pereira, Lima, Jane Palma Galrão   +4 more
core   +3 more sources

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Soroprevalência de anticorpos contra vírus herpes simples 1-2 no Brasil Seroprevalencia de anticuerpos contra virus herpes simples 1-2 en Brasil Seroprevalence of herpes simplex 1-2 antibodies in Brazil

Revista de Saúde Pública, 2010
OBJETIVO: Estimar a soroprevalência de anticorpos por vírus herpes simples (HSV-1 e HSV-2) e analisar fatores associados no Brasil. MÉTODOS: Estudo transversal realizado entre 1996 e 1997 em 1.090 indivíduos com idade entre um e 40 anos da população ...
Sue Ann Costa Clemens, Calil Kairalla Farhat   +1 more
doaj   +1 more source