Results 61 to 70 of about 23,749 (174)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Novel applications of the tomato microbiome: Roles and considerations for agriculture, human health, and society

PLANTS, PEOPLE, PLANET, Volume 8, Issue 2, Page 530-555, March 2026.
Plants, like humans, have a microbiome that helps them grow, defend themselves against pathogens, acquire nutrients, and protect themselves against environmental stresses. The microbiome of tomatoes, a staple crop grown worldwide, could be utilized not only to reduce fertilizer and pesticide applications, but also to clean up harmful pollutants ...
Sean Lindert, Kathryn Kingsley, Peerapol Chiaranunt, James F. White   +3 more
wiley   +1 more source

Diagnosis and Outcome of Herpes Simplex Encephalitis

Pediatric Neurology Briefs, 2007
Children with herpes simplex encephalitis (HSE) admitted to the Hospital for Sick Children, Toronto, Canada, between Jan 1994 and Dec 2005, were studied prospectively.
J Gordon Millichap
doaj   +1 more source

Proteomic Analysis of Cerebrospinal Fluid from Severe COVID‐19 Patients Reveals Prognostic Biomarkers Associated with Disease Outcome

PROTEOMICS – Clinical Applications, Volume 20, Issue 2, March 2026.
ABSTRACT Purpose Coronavirus disease 2019 (COVID‐19) has highlighted significant neurological complications in severe cases. Cerebrospinal fluid (CSF) proteomics could reveal biomarkers related to clinical outcome among critically ill patients. Experimental Design We performed high‐resolution proteomic analyses of CSF samples from 29 intensive care ...
Harry Alexopoulos, Martina Samiotaki, Eirini Gkogkou, Sofia Mavromati, Kleopatra Bitzogli, Georgios Panagiotou, Athanasios Tzioufas, Eleni Magira, Αnastasia Kotanidou, Ioannis Trougakos   +9 more
wiley   +1 more source

Association of Haematological Parameters With TLR Genes in Healthy and Distemper‐Infected Dogs Haematology and TLRs in Distemper

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
The distemper‐infected dogs presented with an upregulated expression of the immune recognition receptors TLR3, TLR4 and TLR9. In the distemper‐infected dogs, there was a positive correlation between the TLR1 and PWD, TLR4 and WBC, Gran and Gran%, TLR5 and HCT, TLR6 and Gran%, TLR7 and MCV and TLR7 and PDW, as well as a negative correlation between the ...
İlknur Karaca Bekdik, Fadime Daldaban, Korhan Arslan, Bilal Akyüz, Öznur Aslan   +4 more
wiley   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

MRI diagnosis of herpes simplex encephalitis in an elderly man with nonspecific symptoms

Radiology Case Reports, 2017
A 78-year-old male presented to the Emergency Department complaining of a 1-week onset of increasing fatigue and anorexia. The patient was previously well but had a history of depression, chronic diarrhea, and hypertension. His examination was remarkable
Benjamin J. Croll, BS, Zachary M. Dillon, MD, Kevin R. Weaver, DO, Marna Rayl Greenberg, DO, MPH   +3 more
doaj   +1 more source

NAD+ Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
JEV infection in brain tissue triggers inflammation and stress in neuronal cells, leading to NAD+ depletion via the overactivation of PARPs and SIRTs. While compensatory biosynthetic pathways (de novo and salvage) were upregulated, the NAD+ level fell critically. In vitro NAMPT inhibition exacerbates this deficit and viral load.
Takele Adugna Kassegn, Zhancheng Tian, Junzheng Du, Qingli Niu, Jifei Yang, Zhang Hongge, Yuqing Song, Fengxue Chai, Zhonghui Zhang, Guiquan Guan, Hong Yin   +10 more
wiley   +1 more source

Herpes Simplex Type 1 Encephalitis Restricted to the Brainstem in a Pediatric Patient

Case Reports in Medicine, 2010
Herpes simplex encephalitis is a potentially fatal infection of central nervous system that typically involves frontal and temporal lobes. Occasionally, it presents an extratemporal involvement and in rarer cases, it is limited to the brainstem.
Juliana Harumi Arita, Jaime Lin, Mirella Maccarini Peruchi, Marcelo Masruha Rodrigues, Luiz Celso Pereira Vilanova   +4 more
doaj   +1 more source

A Case of Herpes Simplex Virus-1 Encephalitis from a Medicolegal Point of View

Case Reports in Medicine, 2018
We present a case of herpes simplex virus-1 encephalitis (HSVE) and discuss the difficulty of early diagnosis and the possibility of a wrong or delayed diagnosis and treatment of this encephalitis.
Alessandro Feola, Anna Mancuso, Mauro Arcangeli   +2 more
doaj   +1 more source