Results 131 to 140 of about 50,832 (209)
In this double‐blind randomized controlled trial, preoperative 10‐Hz rTMS targeting the left DLPFC reduced postoperative delirium within 7 days in older adults undergoing elective non‐cardiac surgery compared with sham stimulation and was well tolerated.
Wen‐Bo Gao +9 more
wiley +1 more source
ABSTRACT Background While immune checkpoint inhibitors (ICIs) have shown significant efficacy, a common side effect is cutaneous immune‐related adverse events (irAEs). This study focuses on exploring the association between specific human leukocyte antigen (HLA) alleles and the development of cutaneous irAEs in melanoma patients undergoing ICI ...
Mckenzie DiLeo +12 more
wiley +1 more source
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley +1 more source
Clinical Presentation of Shoulder‐Hand Syndrome: A Systematic Review
ABSTRACT Background Shoulder‐hand syndrome (SHS) is a neurological disorder characterised by pain, loss of function, and trophic changes in the shoulder and hand of the affected limb. SHS shares a number of features with Complex Regional Pain Syndrome (CRPS).
Rebecca Mountford +11 more
wiley +1 more source
ABSTRACT Objective This study aims to analyze the primary factors influencing the therapeutic effect of pregabalin combined with lidocaine in patients with post‐herpetic neuralgia (PHN). Methods Clinical data of 97 PHN patients admitted to our hospital from January 2022 to October 2024 were retrospectively analyzed.
Xinkai Wang +3 more
wiley +1 more source
This retrospective cohort study indicates that patients with Kikuchi–Fujimoto disease demonstrated immunosuppression characterized by decreased counts of circulating CD3+ and CD4+ lymphocytes. Moreover, serum ferritin levels were inversely correlated with CD4+ lymphocyte counts, suggesting a potential role of ferritin in immune dysregulation in Kikuchi–
Peng Zhong +3 more
wiley +1 more source
ABSTRACT Recently, cases of human infection with rat hepatitis E virus (ratHEV, Rocahepevirus ratti) have been reported worldwide. Due to the significant genetic differences between ratHEV and human HEV genotypes 1–4 (Paslahepevirus balayani), current HEV diagnostic assays are unable to detect ratHEV.
Jessica Panajotov +14 more
wiley +1 more source
Perioperative utilization of JAK inhibitors in Perianal Fistulizing Crohn's disease
Abstract With the recent approval of small molecule drugs such as upadacitinib in adult inflammatory bowel disease (IBD), their utilization is becoming more common; however, there is limited data on perioperative risks or optimal timing of cessation and resumption to mitigate flares. Current recommendations suggest holding these medications for 14 days
Alexander Lyons +2 more
wiley +1 more source
Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu +5 more
wiley +1 more source

