Results 91 to 100 of about 224,084 (383)

Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The phase 3 MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E. Wechsler, Jared Silver, Gerhard Wolff, Robert G. Price, Rejina Verghis, Peter F. Weller, Peter A. Merkel, Paneez Khoury, on behalf of the EGPA Mepolizumab Open‐Label Extension study group, Arnaud Bourdin, Pascal Chanez, Anoop Chauhan, Vincent Cottin, Gerald Gleich, Berhnard Hellmich, Tomonori Ishii, David Jayne, Jean‐Emmanuel Kahn, Peter Kern, Nader Khalidi, Ina Koetter, Carol Langford, Amy Markezich, Paul Monach, Shamsa Naveed, Peter Oelzner, Kenneth Pinna, Xavier Puechal, Emory H. Robinette, Florence Roufosse, Reinhard Voll, Andrew Schafer, Kaharu Sumino, Masami Taniguchi, Phillip Lieberman   +34 more
wiley   +1 more source

Herpes simplex keratitis: Challenges in diagnosis and clinical management [PDF]

, 2017
Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a ...
Azher, Tayaba N, Huang, Andrew JW, Stuart, Patrick M, Tajfirouz, Deena, Yin, Xiao-Tang   +4 more
core   +3 more sources

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Genetic variation in the HLA region is associated with susceptibility to herpes zoster. [PDF]

, 2015
Herpes zoster, commonly referred to as shingles, is caused by the varicella zoster virus (VZV). VZV initially manifests as chicken pox, most commonly in childhood, can remain asymptomatically latent in nerve tissues for many years and often re-emerges as
Armstrong, G, Baldwin, E, Borthwick, KM, Bottinger, E, Burt, A, Carlson, CS, Carrell, DS, Carroll, RJ, Comstock, BA, Crane, PK, Crawford, DC, Crosslin, DR, de Andrade, M, Denny, JC, Doheny, KF, Hanna, DS, Harley, JB, Hayes, MG, Jarvik, GP, Keating, B, Kho, A, Kim, DS, Kuivaniemi, H, Kullo, IJ, Larson, EB, Li, R, McCarty, CA, Mirel, DB, Mukherjee, S, Pacheco, J, Peissig, PL, Pugh, E, Ritchie, MD, Stallings, S, Tromp, G, Underwood, JG, Verma, SS   +36 more
core  

The risk and prognosis of cancer after hospitalisation for herpes zoster: a population-based follow-up study [PDF]

, 2004
We examined the risk of cancer and survival in a cohort of patients hospitalised with herpes zoster between 1977 and 1996, drawn from the Danish National Registry of Patients.
Jepsen, P, Johnsen, S P, Mellemkjær, L, Olsen, J H, Schønheyder, H C, Sørensen, H T   +5 more
core   +2 more sources

Populations Addressed in Vaccines Approved via the European Medicines Agency

Clinical Pharmacology &Therapeutics, EarlyView.
Therapeutic and prophylactic agents require robust evidence before patient use. Randomized controlled trials are essential for evaluating safety and efficacy but often exclude specific populations that are also targets for the intervention. This study assessed which populations are included in vaccine registration studies and/or addressed in label ...
Débora D. Gräf, Lukas Westphal, Jonathan Kimmelman, Christine E. Hallgreen   +3 more
wiley   +1 more source

Serratus Anterior Plane Block in the Emergency Department: A Case Series [PDF]

, 2020
This is a case series of six emergency department (ED) patients who received an ultrasound-guided serratus anterior plane block (SAPB) for a variety of painful conditions.
Badashova, Ksenya, Haines, Lawrence, Hoffman, Taryn, Lin, Judy, Motov, Sergey   +4 more
core  

Regulation of alphaherpesvirus infections by the ICP0 family of proteins [PDF]

, 2013
Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the regulation of lytic and latent viral infection. Like the related proteins expressed by other alphaherpesviruses, ICP0 has a zinc-stabilized RING finger domain that ...
Boutell, Chris, Everett, Roger
core   +1 more source

Rare Occurrence of Herpes Zoster of Trigeminal Nerve following Extraction of Tooth

Case Reports in Dentistry, 2015
Herpes Zoster also known as Shingles is an acute viral infection which is an extremely painful and incapacitating ailment. It results from the reactivation of the varicella zoster virus.
A. Winnifred Christy, T. Jones Raja Deva Thanmbi, J. Leelavathy, Antoinette Rhema Louis   +3 more
doaj   +1 more source

Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2019
Importance Herpes zoster, a frequent complication following autologous hematopoietic stem cell transplantation (HSCT), is associated with significant morbidity.
A. Bastidas, J. de la Serna, Mohamed El Idrissi, L. Oostvogels, P. Quittet, J. López-Jiménez, F. Vural, D. Pohlreich, T. Zuckerman, N. Issa, G. Gaidano, Je-Jung Lee, S. Abhyankar, C. Solano, J. Pérez de Oteyza, M. Satlin, S. Schwartz, M. Campins, A. Rocci, Carlos Vallejo Llamas, Dong‐Gun Lee, S. Tan, A. Johnston, A. Grigg, M. Boeckh, L. Cámpora, Marta López-Fauqued, T. Heineman, E. Stadtmauer, K. Sullivan   +29 more
semanticscholar   +1 more source