Results 1 to 10 of about 20,455 (187)

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways

open access: yesVirology Journal, 2020
Background In the past decades, researchers have demonstrated the critical role of Toll-like receptors (TLRs) in the innate immune system. They recognize viral components and trigger immune signal cascades to subsequently promote the activation of the ...
Xiaofei E, Wei Gao, Zhijun Liu
exaly   +2 more sources

Antiviral and virucidal activity of sodium deoxyribonucleate and its complex with iron against viruses of different kingdoms and families

open access: yesВопросы вирусологии, 2023
Introduction. The urgent problem of modern medicine is the fight against acute respiratory viral infections (ARVI). To combat ARVI, drugs of wide antiviral potency are needed, as well as immunomodulating drugs. Such antiviral and immunomodulatory effects
Dmitry N. Nosik   +8 more
doaj   +1 more source

Emergent Virus Reactivation in SARS-CoV-2-Negative Community Acquired Pneumonia Patients During the COVID-19 Pandemic

open access: yesFrontiers in Microbiology, 2022
Emergent viruses (namely, HSV-1, CMV, and EBV) reactivation were common in critically ill patients and/or immunosuppressed patients. This study aimed to understand the clinical manifestations and reactivation of the emergent viruses in SARS-CoV-2 ...
Junyan Qu, Fang He, Huan Li, Xiaoju Lv
doaj   +1 more source

COVID-19 infection and vaccines: potential triggers of Herpesviridae reactivation

open access: yesAnais Brasileiros de Dermatologia, 2023
Since the onset of the COVID-19 outbreak, numerous articles have highlighted a possible link between COVID-19 vaccination or infection and Herpesviridae co-infection or reactivation.
Alba Navarro-Bielsa   +6 more
doaj   +1 more source

Utility of the Bacteriophage RB69 Polymerase gp43 as a Surrogate Enzyme for Herpesvirus Orthologs

open access: yesViruses, 2013
Viral polymerases are important targets in drug discovery and development efforts. Most antiviral compounds that are currently approved for treatment of infection with members of the herpesviridae family were shown to inhibit the viral DNA polymerase ...
Nicholas Bennett, Matthias Götte
doaj   +1 more source

Special Issue “Replication and Spread of Alphaherpesviruses”

open access: yesViruses, 2022
Alphaherpesviruses, one of three sub-families of the Herpesviridae, are of keen interest to biomedical scientists for several reasons [...]
Stephen A. Rice
doaj   +1 more source

Herpesviridae and microRNAs

open access: yes, 2022
MicroRNAs (miRNAs), first discovered in the year 1993 in the nematode C. elegans, are small, approximately 22-nucleotide-long, non-coding RNAs that regulate gene expression. Cellular miRNAs have been implicated in the control of many biological processes, and their dysregulation is associated with different diseases.
Anwesha Banerjee, Anupam Mukherjee
openaire   +2 more sources

The role of Herpesviridae infection in the progression of comorbid somatic pathology

open access: yesAktualʹnaâ Infektologiâ, 2021
Background. The objective was to study the peculiarities of cellular and humoral immunity in patients with chronic obstructive pulmonary disease (COPD) group B and C, GOLD 2–3, who have signs of metabolic syndrome (MS) and Herpesviridae infection ...
S.A. Bychkova   +2 more
doaj   +1 more source

Prevalence of herpesviruses in gingivitis and chronic periodontitis: relationship to clinical parameters and effect of treatment

open access: yesJournal of Indian Society of Periodontology, 2016
Background: Assess the prevalence of herpesviruses in healthy subjects, gingivitis, and chronic periodontitis patients, to assess the relationship between the prevalence of herpesviruses and periodontal clinical parameters, and to evaluate the effect of ...
Rucha Shah, Dhoom Singh Mehta
doaj   +1 more source

The Essential Co-Option of Uracil-DNA Glycosylases by Herpesviruses Invites Novel Antiviral Design

open access: yesMicroorganisms, 2020
Vast evolutionary distances separate the known herpesviruses, adapted to colonise specialised cells in predominantly vertebrate hosts. Nevertheless, the distinct herpesvirus families share recognisably related genomic attributes.
Renos Savva
doaj   +1 more source

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