Results 141 to 150 of about 1,291,105 (289)

Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation.

PLoS Pathogens, 2019
Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human cancers, such as Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). Current treatment options for KSHV infection and virus associated diseases are sometimes ineffective ...
Jungang Chen, Lu Dai, Alana Goldstein, Haiwei Zhang, Wei Tang, J Craig Forrest, Steven R Post, Xulin Chen, Zhiqiang Qin   +8 more
doaj   +1 more source

Human herpesvirus 6 major immediate early promoter has strong activity in T cells and is useful for heterologous gene expression

Virology Journal, 2011
Background Human herpesvirus-6 (HHV-6) is a beta-herpesvirus. HHV-6 infects and replicates in T cells. The HHV-6-encoded major immediate early gene (MIE) is expressed at the immediate-early infection phase.
Yamanishi Koichi, Takemoto Masaya, Matsuura Masaaki, Mori Yasuko   +3 more
doaj   +1 more source

Fatal Outcome of Multiple Clinical Presentations of Human Herpesvirus 8-related Disease After Solid Organ Transplantation.

Transplantation, 2016
Kaposi sarcoma is the most common human herpesvirus 8 (HHV-8)-related disease described after solid organ transplantation. Multicentric Castleman disease and hemophagocytic syndrome are other potential HHV-8-induced entities but are less frequently ...
S. Vijgen, C. Wyss, P. Meylan, B. Bisig, I. Letovanec, O. Manuel, M. Pascual, L. de Leval   +7 more
semanticscholar   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Involvement of Human Herpesvirus 6 Infection in Renal Dysfunction Associated with DIHS/DRESS.

Acta Dermato-Venereologica, 2016
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/ DRESS) is a life-threatening multi-organ hypersensitivity reaction that appears after prolonged exposure to a limited number of drugs. DIHS/DRESS is often
K. Miyashita, C. Shobatake, F. Miyagawa, N. Kobayashi, Rie Onmori, Shinsuke Yonekawa, Kaori Tanabe, K. Kawate, Kohei Morita, H. Asada   +9 more
semanticscholar   +1 more source

Parvovirus B19‐associated myocarditis in children: A systematic review of clinical features, management and outcomes

European Journal of Clinical Investigation, EarlyView.
This systematic review summarizes clinical features, diagnostic strategies and outcomes of paediatric myocarditis associated with Parvovirus B19. Affected children are typically under 3 years old and often present with fulminant symptoms, severe cardiac dysfunction and a high need for ICU‐level support or mechanical circulatory assistance.
Giacomo Veronese, Giada Colombo, Andrea Garascia, Rachele Adorisio, Ezio Bonanomi, Enrico Ammirati   +5 more
wiley   +1 more source

Pathogenic, Molecular, and Immunological Properties of a Virus Associated with Sea Turtle Fibropapillomatosis. Phase II : Viral Pathogenesis and Development of Diagnostic Assays [PDF]

, 2000
Research conducted under this RWO from July 1, 1997 through June 30, 2000 has provided important new information about the pathogenesis, virology, and immunology of marine turtle fibropapillomatosis. In particular, we have provided strong evidence for
Bjorndal, Karen A., Bolten, Alan, Brown, Daniel R., Coberley, Sadie, Ehrhart, Llewellyn, Herbst, Lawrence H., Klein, Paul A., Lackovich, Joel K., Moretti, Ritchie H.   +8 more
core  

Acute neurologic presentation of a 2‐year‐old standardbred colt with multicentric diffuse large B cell lymphoma

Equine Veterinary Education, EarlyView.
Summary Lymphoma in horses is uncommon and rarely diagnosed as a cause of ataxia. This case report describes a 2‐year‐old Standardbred cryptorchid colt who presented with acute onset of grade 3–4/5 spinal ataxia in all four limbs, with the hindlimbs more severely affected than forelimbs and severe proprioceptive deficits.
K. MacMillan, J. Burns, E. John, M. Buote   +3 more
wiley   +1 more source

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]

, 2008
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna, Chowdhury, Shafiqul I., Daus, Franz, Heemskerk, Mirjam H. M., Koch, Joachim, Koppers-Lalic, Danijela, Lipinska, Andrea D., Loch, Sandra, Marcondes Rezende, Marisa, Mettenleiter, Thomas C., Neefjes, Jacques J., Osterrieder, Nikolaus, Quinten, Edwin, Reits, Eric A., Ressing, Maaike E., Rijsewijk, Frans A. M., Tampé, Robert, Verweij, Marieke C., Wang, Ying, Wiertz, Emmanuel J. H. J.   +19 more
core  

Update on Infection with Varicella-Zoster Virus in Children: A Narrative Review

Indian Journal of Paediatric Dermatology
Varicella-zoster virus (VZV) belongs to the family Herpesviridae. Primary infection with VZV is very high contagious with airborne transmission. VZV can be lifelong latent in cranial nerve and dorsal root ganglia. If it reactivates from infected neurons,
Uwe Wollina, Anca E. Chiriac, Anca Chiriac   +2 more
doaj   +1 more source