Results 171 to 180 of about 1,291,105 (289)

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, Volume 47, Issue 8, August 2025.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

Elucidation of the Hemostatic and Anti‐Inflammatory Effects of Walnut Shell Ethanol Extract by Network Pharmacology and Experimental Verification

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Forty‐five components of WSEE were identified by UPLC‐Q‐TOF‐MS. The main targets of WSEE were PTPN2, ADRB2, LTA4H, and so on in wound healing. WSEE has an anti‐inflammatory effect in LPS‐stimulated RAW264.7 cells, procoagulant activity in vitro, and shortens hemostasis time in vivo.
Ying He, Wenhui Zhao, Yanting Sun, Lei Ma, Censhu Li, Xueying Zheng, Zeguo Feng, Hui Guo, Liguo Qin, Yali Zhang   +9 more
wiley   +1 more source

Herpes zoster oftálmico en pacientes con cáncer de pulmón Ophthalmic herpes zoster in patients with lung cancer

Medisan, 2009
Se presentan 2 casos clínicos de ancianos con cáncer del pulmón, que acudieron al Servicio de Dermatología del Hospital General Docente “Dr. Juan Bruno Zayas Alfonso” por presentar dolor y lesiones maculares, eritematosas y vesiculosas en la región ...
Nancy Téllez Céspedes, Ana Lucía Jacas Portuondo, René Oscar Estrada Ortiz, Natacha López Pupo, Ana Iris Ge Grant   +4 more
doaj  

A New Next‐Generation Sequencing Approach in Human Cytomegalovirus for the Identification of Antiviral Resistance Mutations and Genotypic Classification

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT This study introduces a new procedure for antiviral resistance analysis and genetic classification of human cytomegalovirus (HCMV) using next‐generation sequencing (NGS) adapted to existing methodologies, aiming for more targets due to the recent use of new antivirals. It expands the classical investigation of mutations in UL54 and UL97 genes,
Maria Arnedo‐Muñoz, Ignasi Prats‐Méndez, Alejandra Gónzalez‐Sánchez, Maria Carmen Martín, Ariadna Rando‐Segura, Ibai Los Arcos, Patricia Nadal‐Barón, Narcís Saubi, Natalia Mendoza‐Palomar, Marta Bernat‐Sole, Adaia Albasanz‐Puig, Maria Piñana, Cristina Andrés, Susana Melendo‐Pérez, Nieves Larrosa, Andrés Antón, Juliana Esperalba   +16 more
wiley   +1 more source

Novel Cereblon‐Binding Immunomodulators Have Increased Potency Against Gammaherpesvirus‐ Associated Lymphomas In Vitro

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Primary effusion lymphoma (PEL), which is caused by Kaposi sarcoma herpesvirus (KSHV), and Burkitt lymphoma (BL), a subset of which are associated with Epstein‐Barr virus (EBV), are aggressive non‐Hodgkin's lymphomas. Both have relatively poor survival compared to other lymphomas. Cereblon‐binding immunomodulators (CBIs), such as pomalidomide (
Prabha Shrestha, Emma N. Treco, David A. Davis, Robert Yarchoan   +3 more
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Functional Homologies between Avian and Human Alphaherpesvirus VP22 Proteins in Cell-to-Cell Spreading as Revealed by a New cis-Complementation Assay

Journal of Virology, 2008
C. Blondeau, D. Marc, K. Courvoisier, J. Vautherot, C. Denesvre   +4 more
semanticscholar   +1 more source

Efficacy of High‐Dose Intravenous Anakinra in Pediatric TAFRO Syndrome: Report of Two Cases and Literature Review

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri, Jacopo Ferro, Valentina Natoli, Caterina Matucci‐Cerinic, Riccardo Papa, Silvia Rosina, Stefania Sorrentino, Stefano Volpi, Valerio Gaetano Vellone, Marco Gattorno, Roberta Caorsi   +10 more
wiley   +1 more source

Varicella-Zoster Virus Expresses Multiple Small Noncoding RNAs

Journal of Virology, 2017
Amos Markus, Linoy Golani, N. K. Ojha, Tatiana Borodiansky-Shteinberg, P. Kinchington, R. S. Goldstein   +5 more
semanticscholar   +1 more source

Protease mimicry: Dissecting the ester bond crosslinking mechanics in bacterial adhesin proteins

Protein Science, Volume 34, Issue 8, August 2025.
Abstract The ester bond crosslink discovered within bacterial adhesin proteins offers a captivating insight into the convergent evolution of enzyme‐like machinery. Crystal structures reveal a putative catalytic triad comprising an acid–base–nucleophile combination and an oxyanion‐like site that suggests a serine protease‐like mechanism drives the ...
Yuliana Yosaatmadja, Vanessa Ung, Xinlu Liu, Yixuan Zhao, Julia K. Wardega, Aria Shetty, Sophie Schoensee, Ivanhoe K. H. Leung, Jeremy R. Keown, David C. Goldstone, Edward N. Baker, Paul G. Young, Davide Mercadante, Christopher J. Squire   +13 more
wiley   +1 more source