Results 241 to 250 of about 636,801 (264)

Surveillance of Active Human Herpesvirus 6 Infection in Chinese Patients after Hematopoietic Stem Cell Transplantation with 3 Different Methods

International Journal of Hematology, 2006
Human herpesvirus 6 (HHV-6) reactivation was studied in 72 consecutive allogeneic hematopoietic stem cell transplant (HSCT) recipients and 53 "healthy" donors. The feasibilities of real-time quantitative polymerase chain reaction (RQ-PCR), nested-PCR, and antigenemia assays in the assessment of HHV-6 reactivation were also evaluated.
Lujia Dong, Dao-Pei Lu, Li-Ru Wang
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Effect of recombinant DNA-derived bovine and human interferons on replication of bovine herpesvirus-1, parainfluenza-3, and respiratory syncytial viruses

American Journal of Veterinary Research, 1986
SUMMARY Antiviral effects of recombinant DNA-derived bovine (Bo) and human (Hu) interferons (ifn) on the replication of bovine herpesvirus-1, parainfluenza-3, and respiratory syncytial viruses were studied. Bovine monolayer cultures were treated with recombinant DNA-produced Bo ifn-α 1, Bo ifn-β 2, Hu ifn-α A, or Hu ifn-α A/D and then challenge exposed
R W, Fulton, L J, Burge, J S, McCraken
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The association between fructosamine-3 kinase 900C/G polymorphism, transferrin polymorphism and human herpesvirus-8 infection in diabetics living in South Kivu

Acta Tropica, 2016
Prevalences of human herpesvirus-8 (HHV-8) infection and diabetes mellitus are very common in certain parts of Africa, containing iron-rich soils. We hypothesized that some genetic factors could have a link with susceptibility to HHV-8 infection. We focused on ferroportin Q248H mutation (rs11568350), transferrin (TF) polymorphism and fructosamine-3 ...
Justin C. Cikomola, Justin C. Cikomola, Philippe Bianga Katchunga, Antoine Sadiki Kishabongo, Elizaveta Padalko, Karl Vandepoele, Joris R. Delanghe, Marijn M. Speeckaert   +7 more
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Fine mapping of an apparently targeted latent human herpesvirus type 6 integration site in chromosome band 17p13.3

Journal of Medical Virology, 1999
An unusually high level of latent HHV-6 infection has been documented in the peripheral blood and/or bone marrow cells of a small group of patients with predominantly malignant lymphoid disorders, and in at least one healthy individual. We have shown previously in peripheral blood mononuclear cells (PBMCs) of three patients, two with a history of ...
Morris C, LUPPI, Mario, McDonald M, BAROZZI, Patrizia, TORELLI, Giuseppe   +4 more
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Optimization of chemical induction conditions for human herpesvirus 8 (HHV-8) reactivation with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) from latently-infected BC-3 cells

Biologicals, 2011
Human herpesvirus 8 (HHV-8) persists as episomal DNA in latently-infected cells and can establish two alternative life cycles, latent or lytic. 12-O-tetradecanoyl-phorbol-13-acetate (TPA) is a known inducer of HHV-8 in several human primary effusion lymphoma cell lines and has been widely used for HHV-8 reactivation; however, induction conditions have ...
Arifa S. Khan, Hailun Ma, Yunkun Ma, Teresa A. Galvin, Jacqueline Muller, Wenbin Ma   +5 more
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4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as Non-Nucleoside Inhibitors of Human Cytomegalovirus and Related Herpesvirus Polymerases

Journal of Medicinal Chemistry, 2005
A novel series of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potential antivirals against human herpesvirus infections resulting from human cytomegalovirus (HCMV), herpes simplex virus type 1 (HSV-1), and varicella-zoster virus (VZV).
Nancee L. Oien, Fred L. Homa, Michele M. Cudahy, Roger A. Poorman, Todd A. Hopkins, Janet L. Wieber, Mary L. Knechtel, Roger J. Brideau, Mark E. Schnute, Thomas W. Pitts, Michael W. Wathen   +10 more
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Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition

Bioorganic & Medicinal Chemistry Letters, 2008
A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
Robert S. Sackett, Michele M. Cudahy, Todd A. Hopkins, Michael W. Wathen, Mark E. Schnute, Mari L. Stephan, Sarah A. Collier, Roger J. Brideau, Janet L. Wieber, Allen Scott, Mary L. Knechtel, Nancee L. Oien   +11 more
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ChemInform Abstract: Synthesis of 4‐Oxo‐4,7‐dihydrofuro[2,3‐b]pyridine‐5‐carboxamides with Broad‐Spectrum Human Herpesvirus Polymerase Inhibition.

ChemInform, 2008
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mark E. Schnute, et al. et al.
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2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

Bioorganic & Medicinal Chemistry Letters, 2007
A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
Marijean Eggen, Sajiv Krishnan Nair, Michael W. Wathen, Michele M. Cudahy, Valerie A. Vaillancourt, Todd A. Hopkins, Mary L. Knechtel, Roger J. Brideau, Sarah A. Collier, Mark E. Schnute, Janet L. Wieber, James A. Nieman, Allen Scott, Steven P. Tanis, Fred L. Ciske, Euibong J. Kim, Thomas M. Judge, Nancee L. Oien, Michael J. Genin, David J. Anderson   +19 more
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A cytotoxic effect associated with 9-(1,3-dihydroxy-2-propoxymethyl)-guanine is observed during the selection for drug resistant human cells containing a single herpesvirus thymidine kinase gene

Biochemical and Biophysical Research Communications, 1985
A cytotoxic effect associated with 9-(1,3-dihydroxy-2-propoxymethyl)-guanine (DHPG) was discovered while searching for spontaneous mutations in a single copy, integrated HSV-1 thymidine kinase (TK) gene in the human 143 TK- cell line. It was found that spontaneous DHPGR mutations could not be selected while other anti-TK drugs resulted in selectable ...
Michael S. DuBow, Daphne R. Goring
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