Results 61 to 70 of about 641,507 (252)

Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future [PDF]

, 2015
Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy.
CIRONE, Mara, FAGGIONI, Alberto, FARINA, Antonella, GONNELLA, ROBERTA, GRANATO, Marisa, SANTARELLI, Roberta, TRIVEDI, PANKAJ   +6 more
core   +4 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Use of Staged Molecular Analysis to Determine Causes of Unexplained Central Nervous System Infections

Emerging Infectious Diseases, 2013
No agent is implicated in most central nervous system (CNS) infections. To investigate cerebrospinal fluid samples from patients with CNS infections of unknown cause in 1 hospital in Taiwan, we used a staged molecular approach, incorporating techniques ...
Chien-Chin Hsu, Rafal Tokarz, Thomas Briese, Hung-Chin Tsai, Phenix-Lan Quan, W. Ian Lipkin   +5 more
doaj   +1 more source

Further strategies for evaluating the etiological role of a tumor-associated herpesvirus in marine turtle fibropapillomatosis [PDF]

, 2001
In 1992, an interdisciplinary research team headquartered at the University of Florida began studies in key targeted areas of fibropapillomatosis (FP) etiology and pathogenesis.
Jacobson, Elliott, Klein, Paul A.
core  

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, EarlyView.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.

PLoS Pathogens
Apoptosis is a critical host antiviral defense mechanism. But many viruses have evolved multiple strategies to manipulate apoptosis and escape host antiviral immune responses.
Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang, Changjiang Weng   +7 more
doaj   +1 more source

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques [PDF]

, 2016
Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations that occur in the setting of depressed T-cell function due to immunosuppressive therapy used following solid organ transplantation, hematopoietic ...
Aron Badin, R., Cavicchioli, L., Cozzi, E., Crossan, C., Danesi, A., Ferraresso, S., Hantraye, P., Kaliyaperumal, S., Knight, H., Scobie, L., Trez, D., Vadori, M., Westmoreland, S.   +12 more
core   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Genetic characterization of alloherpesvirus (cyprinid herpesvirus-2 and koi herpesvirus) and poxvirus (carp edema virus) identified from domestic and imported cyprinids in Korea

Fisheries and Aquatic Sciences, 2023
Cyprinids are popular species for aquaculture worldwide, with Asia being a significant contributor to their production. In Korea, common carp (Cyprinus carpio), koi carp (Cyprinus rubrofuscus), and goldfish (Carassius auratus) are cultivated domestically
Ye Jin Jeong, Yu Gyeong Jeon, Hee Ju Choi, Eun Jin Baek, Guk Hyun Kim, Yun Jung Yang, Min Jae Kim, Joon Gyu Min, Kwang Il Kim   +8 more
doaj   +1 more source

A Very Strong Enhancer Is Located Upstream of an Immediate Early Gene of Human Cytomegalovirus [PDF]

, 1985
A strong transcription enhancer was identified in the genomic DNA (235 kb) of human cytomegalovirus (HCMV), a ubiquitous and severe pathogen of the herpesvirus group.
Boshart, Michael, Dorsch-Häsler, Karoline, Fleckenstein, Bernhard, Jahn, Gerhard, Schaffner, Walter, Weber, Frank   +5 more
core   +1 more source