Results 91 to 100 of about 1,113,719 (248)

T cells from newly diagnosed multiple sclerosis patients have enhanced responsiveness to CD46 activation

Clinical and Experimental Neuroimmunology, EarlyView.
Abstract Objective To evaluate the responsiveness of T cells from newly diagnosed multiple sclerosis (MS) patients to CD46 co‐stimulation, a membrane co‐factor protein potentially involved in MS pathogenesis. Methods T cells from MS patients and non‐diseased symptomatic controls (SC) were activated in vitro with or without αCD46 antibody co‐stimulation.
Linda Sundvall, Litten S. Rossen, Vivien R. Schack, Bettina Bundgaard, Peter V. Rasmussen, Thor Petersen, Per Höllsberg   +6 more
wiley   +1 more source

The S‐Phase Arrest of Host Cells Caused by an Alpha‐Herpesvirus Genome Replication Facilitates Viral Recruitment of RNA Polymerase II to Transcribe Viral Genes

Cell Proliferation, EarlyView.
Viral infection arrests host cells in the S phase, which promotes vDNA synthesis and vRC formation, further facilitating viral recruitment of RNA Pol II to preferentially transcribe viral genes. ABSTRACT Herpesviruses rely on host RNA polymerae II (RNA Pol II) for their mRNA transcription, yet the mechanisms of which has been poorly defined, while ...
Qiqi Yang, Ying Wu, Mingshu Wang, Shun Chen, Renyong Jia, Qiao Yang, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Yu He, Zhen Wu, Anchun Cheng   +16 more
wiley   +1 more source

Wound, pressure ulcer, and burn guidelines (2023)―4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers, third edition

The Journal of Dermatology, EarlyView.
Yoshihide Asano, Jun Asai, Takayuki Ishii, Yohei Iwata, Masanari Kodera, Chie Miyabe, Akihiko Uchiyama, Youichi Ogawa, Ken Okamura, Mari Kishibe, Yuta Koike, Yorihisa Kotobuki, Noriki Fujimoto, Takuya Miyagi, Yukie Yamaguchi, Ayumi Yoshizaki, Reiko Omori, Takeshi Nakanishi, Hiroshi Fujiwara, Takeo Maekawa, Sei‐ichiro Motegi, Yuichiro Yoshino, Minoru Hasegawa, Manabu Fujimoto, Takao Tachibana, Wound, Pressure Ulcer, and Burn Guidelines Drafting Committee (connective tissue disease/vasculitis group)   +27 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Successful Treatment of Human Herpesvirus 6 Encephalomyelitis in Immunocompetent Patient

Emerging Infectious Diseases, 2004
We report the case of human herpesvirus 6 (HHV-6) encephalomyelitis in an immunocompetent patient, which was confirmed by viral amplification from cerebrospinal fluid. Cidofovir was used followed by ganciclovir because of an adverse effect to probenecid.
Eric Denes, Laurent Magy, Karine Pradeau, Sophie Alain, Pierre Weinbreck, Sylvie Ranger-Rogez   +5 more
doaj   +1 more source

Latent human herpesvirus 6 is reactivated in CAR T cells

Nature, 2023
C. Lareau, Yajie Yin, K. Maurer, Katalin D. Sandor, Bence Daniel, Garima Yagnik, José Peña, J. Crawford, A. Spanjaart, Jacob C. Gutierrez, N. Haradhvala, J. Riberdy, Tsion Abay, Robert R. Stickels, Jeffrey Verboon, Vincent Liu, Frank A. Buquicchio, Fangyi Wang, Jackson Southard, Ren Song, Wenjin Li, Aastha Shrestha, L. Parida, G. Getz, M. Maus, Shuqiang Li, Alison Moore, Zachary J. Roberts, Leif S. Ludwig, Aimee C. Talleur, Paul G. Thomas, H. Dehghani, Thomas Pertel, Anshul Kundaje, Stephen Gottschalk, Theodore L. Roth, M. J. Kersten, Catherine J. Wu, R. Majzner, Ansuman T. Satpathy   +39 more
semanticscholar   +1 more source

Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study.

Clinical Infectious Diseases, 2013
BACKGROUND The epidemiology of human herpesvirus 6 (HHV-6) encephalitis after allogeneic hematopoietic cell transplantation (HCT) and its relationship with HHV-6 reactivation have not been sufficiently characterized.
M. Ogata, T. Satou, J. Kadota, Noriyuki Saito, Takashi Yoshida, H. Okumura, T. Ueki, K. Nagafuji, S. Kako, N. Uoshima, M. Tsudo, H. Itamura, T. Fukuda   +12 more
semanticscholar   +1 more source

Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review

European Journal of Clinical Investigation, EarlyView.
Abstract Background Torque teno virus (TTV) is not known to cause disease in humans; however, chronic inflammatory conditions and immunosuppression states can favour TTV replication. This study aimed to verify the effectiveness of TTV as an immune biomarker.
Janaina B. Medina, Fábio França Vieira e Silva, Rafael Antônio Velôso Caixeta, Bruna de Oliveira Rech, Alba Perez‐Jardón, María Elena Padín‐Iruegas, Mario Pérez‐Sayáns, Paulo Henrique Braz‐Silva, Karem L. Ortega   +8 more
wiley   +1 more source

The cerebellum in epilepsy

Epilepsia, EarlyView.
Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder, Rebecca Kerestes, Puneet Opal, Maria Marchese, Orrin Devinsky   +4 more
wiley   +1 more source

Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome

Nucleic Acids Research, 2013
Linear chromosomes are stabilized by telomeres, but the presence of short dysfunctional telomeres triggers cellular senescence in human somatic tissues, thus contributing to ageing.
Y. Huang, Alberto Hidalgo-Bravo, E. Zhang, V. Cotton, A. Mendez-Bermudez, G. Wig, Zahara Medina-Calzada, R. Neumann, A. Jeffreys, B. Winney, James F. Wilson, D. A. Clark, M. Dyer, N. Royle   +13 more
semanticscholar   +1 more source