Results 51 to 60 of about 630,160 (249)

Human herpesvirus 6 infection impairs Toll-like receptor signaling

Virology Journal, 2010
Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent cells, including T lymphocytes, monocytes/macrophages, and dendritic cells (DCs) suggesting that HHV-6 infection affects the immunosurveillance system. Toll-like receptor (TLR) system plays an
Ochi Toshiki, Suemori Koichiro, An Jun, Fujiwara Hiroshi, Tanimoto Kazushi, Murakami Yuichi, Hasegawa Hitoshi, Yasukawa Masaki   +7 more
doaj   +1 more source

Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy [PDF]

, 2017
KSHV and EBV are gammaherpesviruses strictly linked to human cancers. Even if the majority of cancer cells harbor a latent infection, the few cells that undergo viral replication may contribute to the pathogenesis and maintenance of the virus-associated ...
Cirone, Mara, Faggioni, Alberto, Gilardini Montani, Maria Saveria, Gonnella, Roberta, Granato, Marisa, Romeo, Maria Anele, Santarelli, Roberta, Tiano, Mariangela Sara   +7 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Inherited Chromosomally Integrated Human Herpesvirus 6: Laboratory and Clinical Features

Microorganisms, 2023
Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the chromosomes of the host germ cell and is vertically transmitted.
Liliana Gabrielli, Alice Balboni, Eva Caterina Borgatti, Giulio Virgili, Evangelia Petrisli, Alessia Cantiani, Matteo Pavoni, Federico Baiesi Pillastrini, Simona Venturoli, Giulia Piccirilli, Tiziana Lazzarotto   +10 more
doaj   +1 more source

Human Herpesvirus 6 and Neuroinflammation [PDF]

ISRN Virology, 2013
Human herpesvirus (HHV-) 6A and HHV-6B are two distinctβ-herpesviruses which have been associated with various neurological diseases, including encephalitis, meningitis, epilepsy, and multiple sclerosis. Although the reactivation of both viruses is recognized as the cause of some neurological complications in conditions of immunosuppression, their ...
Reynaud, Joséphine M., Horvat, Branka
openaire   +2 more sources

Primary replication and invasion of the bovine gammaherpesvirus BoHV-4 in the genital mucosae [PDF]

, 2017
Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus that is widespread in cattle. Ex vivo models with bovine genital tract mucosa explants were set up to study molecular/cellular BoHV-4-host interactions.
Bogado Pascottini, Osvaldo Américo, Li, Yewei, Nauwynck, Hans, Opsomer, Geert, Wei, Ruifang, Xie, Jiexiong, Yang, Bo   +6 more
core   +2 more sources

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, EarlyView.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation [PDF]

, 2013
Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13
Ahmad, B. Tolani, Ballon, Benhamou, Bower, Bren, C. Graham, Chang, Chaudhary, Chugh, Delmore, Dong, Du, Dupin, Dupin, Eeva, Eeva, Field, Gerondakis, Guasparri, H. Matta, H. Yi, Hassman, Herzog, Lee, Liu, Madureira, Matta, Matta, Matta, Matta, Mineva, Nador, Niiro, P. M. Chaudhary, Parravicini, Punj, Schauer, Soulier, Sun, Sun, Sun, Thome, Vrzalikova, Waterston, Wu, Wu, Wu, Y. Suo, Y. Yang, Yang, Yang, Young, Zhao   +53 more
core   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques [PDF]

, 2016
Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations that occur in the setting of depressed T-cell function due to immunosuppressive therapy used following solid organ transplantation, hematopoietic ...
Aron Badin, R., Cavicchioli, L., Cozzi, E., Crossan, C., Danesi, A., Ferraresso, S., Hantraye, P., Kaliyaperumal, S., Knight, H., Scobie, L., Trez, D., Vadori, M., Westmoreland, S.   +12 more
core   +1 more source