Results 31 to 40 of about 27,678 (227)

Enhancing Adeno‐Associated Virus 2 Capsid Engineering Through Co‐Evolutionary Coupling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated virus (AAV) has emerged as a leading platform for gene therapy. However, to unlock the full potential, their manufacturing yields, stability, and efficacy must all be improved. Rational design is limited by poor predictability and the potential impact of mutations on multiple important vector properties.
Sirimar Laosinwattana, Yiwen Li, Braulio Carrillo Sanchez, Ayesha Khan, Paul A. Dalby   +4 more
wiley   +1 more source

Structural compatibility between β‐lactams and substrate binding pockets of IMP‐1 and NDM‐1 determines the substrate spectrum

Bulletin of the Korean Chemical Society, EarlyView.
Chemical structures of three β‐lactam classes and the substrate‐binding pockets (SBPs) of B1 metallo‐β‐lactamases (MBLs) were compared. Structural compatibility between β‐lactams and MBL SBPs correlates with enzymatic activity, providing insights into the substrate spectrum of MBLs and β‐lactam resistance.
Kiwoong Kwak, Jiwon Yun, Donghyun Lee, Byung‐Jin Lee, Juyeon Lim, Jung Hun Lee, Sang Hee Lee, Soon Young Shin, Lin‐Woo Kang   +8 more
wiley   +1 more source

Green and Smart HRM for Eco‐Innovation: Disruptive Technology, Organisational Digital Capability and Boundary Conditions in Nigerian Manufacturing

Business Strategy and the Environment, EarlyView.
ABSTRACT Manufacturers once pursued dividends and competitive advantage with little regard for environmental harm, a legacy that now compounds global warming. Disruptive technology (DT) and digitalisation both intensify and complicate firms' current eco‐innovation agendas.
Samuel Ogbeibu, Raphael Oseghale, Jude Emelifeonwu, James Gaskin, Vijay Pereira, Mathew Hughes, Richard Nyuur   +6 more
wiley   +1 more source

Investigating associations between hearing, cognition, and social isolation using the Hertfordshire Ageing Study

Frontiers in Public Health
ObjectivesThe aim of the study was to investigate whether hearing threshold separately predicts cognitive score and social isolation score 10 years later by using the Hertfordshire Ageing Study (HAS) data.MethodsThe Hertfordshire Ageing Study (HAS) is a ...
Nisha Dhanda, Amanda Hall, James Martin, Helen Pryce   +3 more
doaj   +1 more source

‘We Need Help Too’—The Forgotten Stakeholders: Exploring the Needs of Carers During Their Young Persons' Transition From Child to Adult Eating Disorder Services

European Eating Disorders Review, EarlyView.
ABSTRACT Background Carers are essential in their young person's recovery during transition from child to adult eating disorder services. Despite recommendations, carer's own needs can be overlooked in transition planning. Subsequently, carers experience distress in supporting their young person and navigating the transition.
Isabel Lenham, Maria Livanou, Anya Heneghan, Grace Hill, Alanta McKenzie, Marta Marlais, Francesca Marshall, Zara Smalley, Eleni Xanthopoulou, Nora Kornai, Jessica Wilks, Ailsa McKay, Jun Teh, Julian Baudinet   +13 more
wiley   +1 more source

Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress

Equine Veterinary Journal, EarlyView.
Abstract Background Lamellar endoplasmic reticulum (ER) stress occurs in hyperinsulinemia‐associated and sepsis‐related laminitis. Adiponectin is associated with reduced laminitis risk and inhibits ER stress in other species. Objectives To induce ER stress in ex vivo equine lamellar cells using pharmacological agents.
Marine A. Barnabé, Jonathan Elliott, Nicola J. Menzies‐Gow, Simon R. Bailey, Nicholas J. Bamford, Yu‐Mei Chang, Matthew C. Gage   +6 more
wiley   +1 more source

Las escuelas de Hertfordshire ¿Un arte de construir en equipo?

Cuaderno de Notas, 2000
El artículo revisa las circunstancias que dieron lugar al establecimiento en el condado inglés de Hertfordshire de un programa para el desarrollo de escuelas en los años inmediatamente posteriores a la II Guerra Mundial, que hizo hincapié en aspectos tan
Roberto Osuna Redondo
doaj  

Development of a prognostic scoring system for systemic inflammatory response syndrome in donkeys

Equine Veterinary Journal, EarlyView.
Abstract Background Systemic inflammatory response syndrome (SIRS) is associated with increased mortality in horses with gastrointestinal (GI) disease. However, there are no data relating to naturally occurring SIRS in donkeys. Objectives To determine SIRS frequency in donkeys with GI disease. To develop a donkey‐specific prognostic SIRS score.
Marine A. Barnabé, Nicholas J. Bamford, Jonathan Elliott, Yu‐Mei Chang, Karen Rickards, Nicola J. Menzies‐Gow   +5 more
wiley   +1 more source

Developing a protocol and experimental setup for using a humanoid robot to assist children with autism to develop visual perspective taking skills

Paladyn, 2019
Visual Perspective Taking (VPT) is the ability to see the world from another person’s perspective, taking into account what they see and how they see it, drawing upon both spatial and social information.
Wood Luke Jai, Robins Ben, Lakatos Gabriella, Syrdal Dag Sverre, Zaraki Abolfazl, Dautenhahn Kerstin   +5 more
doaj   +1 more source

Risk factors for horse falls in British jump racing (2010–2023)

Equine Veterinary Journal, EarlyView.
Abstract Background Horse falls are an important safety and welfare concern in jump racing, as they are associated with an increased risk of equine fatality and injury, as well as jockey injury. Objectives To identify risk factors for horse falls in British jump racing. Study Design Retrospective cohort.
S. E. Allen, S. Taylor, J. Given, K. L. P. Verheyen   +3 more
wiley   +1 more source