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The paradox of functional heterochromatin
BioEssays, 2004Although heterochromatin has been studied for 80 years, its genetic function and molecular organization have remained elusive. In almost all organisms, heterochromatin has been regarded as genetically inactive chromosome regions. However, from genetic and genomic studies in Drosophila melanogaster and other organisms including humans, it is now clear ...
DIMITRI, Patrizio +3 more
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Nature Reviews Molecular Cell Biology, 2012
The sequence-specific transcription factors PAX3 and PAX9 promote heterochromatin formation.
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The sequence-specific transcription factors PAX3 and PAX9 promote heterochromatin formation.
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NOR associations with heterochromatin
Cytogenetic and Genome Research, 1984Associations between nucleolus organizer regions (NORs) and non-acrocentric chromosomes were scored in 2,800 metaphase spreads from PHA-stimulated lymphocyte cultures (48 h) from 14 individuals. The preparations were both silver stained and C-banded.
J. W. Bennett +3 more
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The Origin of Heterochromatin in Eukaryotes
Russian Journal of Genetics, 2002This study is an attempt to reconstruct the stages of the evolution of heterochromatin in eukaryotes. According to the hypothesis put forward in the work, the origin of satellite DNAs (stDNAs) was directly related to certain functional characteristics of DNA polymerases, and stDNAs themselves are products of accidental slippage at replication ...
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Reinterpreting pericentromeric heterochromatin
Current Opinion in Plant Biology, 2006In fission yeast, pericentromeric heterochromatin is directly responsible for the sister chromatid cohesion that assures accurate chromosome segregation. In plants, however, heterochromatin and chromosome segregation appear to be largely unrelated: chromosome transmission is impaired by mutations in cohesion but not by mutations that affect ...
Christopher N. Topp, R. Kelly Dawe
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1967
Publisher Summary The concept of heterochromatin is related to the subject of sex chromosomes and to the phenomenon of sex chromatin. The term “heterochromatin― described a cytological concept, the material basis of the phenomenon of heteropycnosis. “Heterochromatin― became endowed with genetic characteristics. The idea associated with heterochromatin
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Publisher Summary The concept of heterochromatin is related to the subject of sex chromosomes and to the phenomenon of sex chromatin. The term “heterochromatin― described a cytological concept, the material basis of the phenomenon of heteropycnosis. “Heterochromatin― became endowed with genetic characteristics. The idea associated with heterochromatin
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Heterochromatin and histone phosphorylation
Experimental Cell Research, 1978Abstract Histone phosphorylation and nuclear structure have been compared in cultured cell lines of two related species of deer mice, Peromyscus crinitus and Peromyscus eremicus , which differ greatly in their heterochromatin contents but which contain essentially the same euchromatin content.
S.S. Barham +3 more
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METTL3 regulates heterochromatin in mouse embryonic stem cells
Nature, 2021Wenqi Xu +13 more
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Heterochromatin, colchicine, and karyotype
Chromosoma, 1965Species of Chilocorus differ in chromosome number owing to centric fusion of metacentric chromosomes. The concomitant loss of arms is tolerated because in all unfused chromosomes one arm is completely heterochromatic, the other euchromatic. Under the influence of colchicine, the arms of unfused and fused chromosomes contract differentially.
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Perinuclear DNA and heterochromatin
Experimental Cell Research, 1977Abstract We have analyzed how and to what measure DNA which replicates specifically at the nuclear membrane at the end of S phase (perinuclear DNA) correlates with heterochromatin. We found that, although perinuclear DNA can be distinguished in autoradiographs in two different patterns of labelling, these appear to constitute the same heterochromatic
D. Chiatante +3 more
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