A Universal Method for the Synthesis of new Heterocyclic Systems: Pyrimido[2,1‐f][1,2,4]triazines
ChemistryOpenThe synthesis of pyrimido[2,1‐f][1,2,4]triazines was performed in four steps. Compounds obtained by acylation of the starting amino esters of thieno[2,3‐b]pyridines were reacted with various amines.
Samvel N. Sirakanyan +7 more
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A Novel Strategy of Ugi-4CR/Huisgen 1,3-Dipolar Synthesis of 1H-1,2,3-Triazole-Modified Peptidoimetics [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2018 In this protocol, we report a novel approach for the synthesis of a new class of heterocyclic 1H-1,2,3-triazole-modified peptidomimetic compounds. The process consists of an Ugi four-component condensation reaction of amines, an isocyanide, an aldehyde ...
Ahmad Shaabani +4 more
doaj
Induction of glucose production by heterocyclic amines is dependent on N-acetyltransferase 2 genetic polymorphism in cryopreserved human hepatocytes. [PDF]
Toxicol Lett, 2023 Walls KM, Hong KU, Hein DW.
europepmc +1 more source
Chemistry – A European Journal, EarlyView.Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi +6 more
wiley +1 more source
Citrus Peel Extracts: Effective Inhibitors of Heterocyclic Amines and Advanced Glycation End Products in Grilled Pork Meat Patties. [PDF]
Foods, 2023 Xu Y +6 more
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Chemistry – A European Journal, EarlyView.Easily synthesized [Ge([12]crown‐4)2][OTf]2 catalyzes the hydrosilylation of aldehydes to give reductively coupled ethers via a carbonyl‐activated reaction pathway. The mechanism proceeds through two distinct steps: hydrosilylation followed by etherification. The open coordination face of the active cationic Ge(II) catalyst facilitates the coordination
Sarah L. McOnie +2 more
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Effects of Oil and Processing Conditions on Formation of Heterocyclic Amines and Polycyclic Aromatic Hydrocarbons in Pork Fiber. [PDF]
Foods, 2023 Lai YW, Stephen Inbaraj B, Chen BH.
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C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins
Chemistry – A European Journal, EarlyView.C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens +3 more
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Study on the reduction of heterocyclic amines by marinated natural materials in pork belly. [PDF]
J Anim Sci Technol, 2022 Kang HJ +8 more
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Trends and Future Directions in Organic Chemistry for Drug Discovery
Chemistry – A European Journal, EarlyView.Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
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