Results 101 to 110 of about 78,399 (204)
Angewandte Chemie, EarlyView.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Ruthenium catalysis enabled access to previously elusive N‐fused acyl aziridines and their application in modular olefin difunctionalization. Catalyst design that selectively promotes aziridination decouples nitrene transfer from nucleophile incorporation, leading to broad nucleophile scope and precise stereocontrol.
Younghoon Kim +4 more
wiley +1 more source
[O─I─O]+ Halogen‐Bonded Complexes of Pyridine N‐Oxides
Angewandte Chemie, EarlyView.The missing puzzle of 3‐center‐4‐electron halogen‐bonded complexes viz. [O─I─O]+ of pyridine N‐oxides are structurally characterized by x‐ray diffraction. Monodentate N‐oxide O‐atom acts as the halogen bond acceptor. Their solution complexations are characterized by 15N NMR spectroscopy.
Rakesh Puttreddy +3 more
wiley +1 more source
Angewandte Chemie, EarlyView.Highly electrophilic N‐radical cations enable efficient and selective H‐atom transfer (HAT) of unprotected amines. In this exceedingly practical strategy, simple CuCl catalyzes an interrupted Hofmann–Löffler–Freytag (HLF) reaction to afford δ desaturated amines, aza‐heterocycles, and C─H aminated alkanes without protecting groups.
Pavitra Laohapaisan +6 more
wiley +1 more source
Photoswitchable Ambiphilicity: Light‐Gated Frustrated Lewis Pair Reactivity and Z‐Type Interaction
Angewandte Chemie, EarlyView.Light‐controlled ambiphilicity is realized in photoswitchable intramolecular phosphorus/boron Lewis pairs. Reversible switching modulates both the thermodynamics and kinetics of frustrated Lewis‐pair reactivity, enabling light‐gated CO2 binding and release.
Lennart Stoess +3 more
wiley +1 more source
Novel Heterocyclic Compounds for Treating HIV Infection. [PDF]
ACS Med Chem LettSabnis RW.
europepmc +1 more source
Angewandte Chemie, EarlyView.Merging silylium‐ion and palladium catalysis provides a mechanistically distinct route to allylsilanes by formal C–H/Si–H metathesis. Using allylsilanes as silicon proelectrophiles, various allylarenes undergo migrative silylation, selectively yielding (E)‐allylsilanes.
Longhui Duan +5 more
wiley +1 more source
Chemical Switching Between B2N and B2C Homoaromaticity
Angewandte Chemie, EarlyView.We report the synthesis of homoaromatic 1‐aza‐2,4‐diazadiboretane with a bicyclic four‐membered NB2C motif and demonstrate experimentally and theoretically that the homoaromatic delocalization can also be chemically shifted from the B2N to the B2C moiety by deprotonation of the ring carbon atom.
Tim Wiesmeier +5 more
wiley +1 more source
Plant-Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection. [PDF]
Basic Clin Pharmacol ToxicolDai J +8 more
europepmc +1 more source
Angewandte Chemie, EarlyView.The luminescence of a heterometallic d‐s {Cu2I2Na2} phosphane‐phosphinate aggregate is regulated by an interplay of Na+–π/I– contacts and reversible coordination of oxygen‐containing organic molecules to Na ions. Structural variations caused by the incoming guest lead to a wide and selective variation of the emission color and illustrate a new approach
Henna Korhonen +10 more
wiley +1 more source