Results 111 to 120 of about 432,033 (303)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

A Synthesis on Agent-Based Impact Assessment Models from the Perspective of the EU Rural Development Policy Measures

Journal of Agricultural Sciences
The second pillar of the European Union’s (EU) Common Agricultural Policy (CAP) aims at supporting rural areas by meeting the economic, environmental and social challenges. To deal with these challenges, countries are faced with the question of selecting
Rosalia Filippini, Carlos Leyva Guerrero, Pablo Baez Gonzales, Mario Veneziani, Selim Çağatay, Ali Koç, Peyman Uysal   +6 more
doaj   +1 more source

THE REPRESENTATIVE CONSUMER IN THE NEOCLASSICAL GROWTH MODEL WITH IDIOSYNCRATIC SHOCKS [PDF]

This paper studies a complete-market version of the neoclassical growth model, where agents face idiosyncratic shocks to earnings. We show that if agents possess identical preferences of either the CRRA or the addilog type, then the heterogeneous-agent ...
Lilia Maliar, Serguei Maliar
core  

Model Driven Evolution of an Agent-Based Home Energy Management System [PDF]

, 2018
Advanced smart home appliances and new models of energy tariffs imposed by energy providers pose new challenges in the automation of home energy management. Users need some assistant tool that helps them to make complex decisions with different goals,
Amor-Pinilla, Maria Mercedes, Ayala, Inmaculada, Fuentes-Fernández, Lidia, Horcas, José-Miguel   +3 more
core  

Emergence of heterogeneity in an agent-based model

Physica A: Statistical Mechanics and its Applications, 2003
We study an interacting agent model of a game-theoretical economy. The agents play a minority-subsequently-majority game and they learn, using backpropagation networks, to obtain higher payoffs. We study the relevance of heterogeneity to performance, and how heterogeneity emerges.
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

An LLM-Driven Multi-Agent Simulation Framework for Coupled Epidemic–Economic Dynamics

Information
Traditional Agent-based Models (ABMs) often struggle to capture the nuance of adaptive human decision-making during complex crises due to their reliance on static, predefined rules.
Shanrui Wang, Huiyong Liu, Shiyi Zhang, Qunsheng Yang   +3 more
doaj   +1 more source

Agent-Based Model of Price Competition and Product Differentiation on Congested Networks [PDF]

Using consistent agent-based techniques, this research models the decision-making processes of users and infrastructure owner/operators to explore the welfare consequence of price competition, capacity choice, and product differentiation on congested ...
David Levinson, Lei Zhang, Shanjiang Zhu
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source