Results 111 to 120 of about 415,705 (306)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Modeling the student choice–Perception–Realization lifecycle: A methodological framework with synthetic data illustration

open access: yesSocial Sciences and Humanities Open
A student’s choice of higher education institution has enduring consequences extending beyond academics, affecting career trajectories and economic outcomes.
Animesh Karn   +2 more
doaj   +1 more source

An Ontology-based Approach for Knowledge Integration in Product Collaborative Development

open access: yesJournal of Intelligent Systems, 2017
Knowledge integrated model (KIM) is regarded as an effective and critical way to enhance efficiency of product collaborative development (PCD). However, it is much knotty to establish a unified description rule as there exists diverse and heterogeneous ...
Yu Guodong, Yang Yu, Qingsong Xing
doaj   +1 more source

Using genetic algorithms to model the evolution of heterogeneous beliefs [PDF]

open access: yes
Genetic algorithms have been used by economists to model the process by which a population of heterogeneous agents learn how to optimize a given objective.
James Bullard, John Duffy
core  

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Expectational business cycles [PDF]

open access: yes
I introduce Expectational Business Cycles where aggregate activity fluctuates due to learning, heterogeneous updating rules and random changes in the social norm predictor.
Guse, Eran
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Existence of an Equilibrium for Lower Semicontinuous Information Acquisition Functions

open access: yesJournal of Applied Mathematics, 2014
We consider a two-period model in which a continuum of agents trade in a context of costly information acquisition and systematic heterogeneous expectations biases. Because of systematic biases agents are supposed not to learn from others' decisions.
Agnès Bialecki   +2 more
doaj   +1 more source

Unmet goals of tracking: within-track heterogeneity of students' expectations for [PDF]

open access: yes, 2015
Educational systems are often characterized by some form(s) of ability grouping, like tracking. Although substantial variation in the implementation of these practices exists, it is always the aim to improve teaching efficiency by creating homogeneous ...
Demanet, Jannick   +2 more
core   +1 more source

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