Results 31 to 40 of about 260,326 (318)

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Wafer-level heterogeneous 3D integration for MEMS and NEMS

, 2012
In this paper the state-of-the-art in wafer-level heterogeneous 3D integration technologies for micro-electromechanical systems (MEMS) and nano-electromechanical systems (NEMS) is reviewed. Various examples of commercial and experimental heterogeneous 3D
Roxhed, Niclas,, Niclas Roxhed, Michel Despont, Dubois, Valentin,, Niklaus, Frank, Niklaus, Frank,, Valentin Dubois, Stemme, Göran,, Bleiker, Simon J., Grogg, Daniel, Fredrik Forsberg, Frank Niklaus, Forsberg, Fredrik, Roxhed, Niclas, Despont, Michel, Simon J. Bleiker, Stemme, Göran, Fischer, Andreas,, Goran Stemme, Forsberg, Fredrik,, Bleiker, Simon J.,, Daniel Grogg, Martin Lapisa, Lapisa, Martin, Fischer, Andreas, Dubois, Valentin, Lapisa, Martin,, Andreas C. Fischer   +27 more
core   +1 more source

Extraction of Inherent Amplitude Mode from a Light Beam

Advanced Photonics Research
Mode extraction is the inverse process of the double‐beam superposition principle in classical optics. While polarization mode extraction has been successfully demonstrated using an m‐order vector vortex beam, amplitude mode extraction remains a ...
Zhiyang Xia, Xiaoyu Weng, Liwei Liu, Jun He, Changrui Liao, Yiping Wang, Junle Qu   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Grid-based semantic integration of heterogeneous data resources: Implementation on a HealthGrid [PDF]

, 2007
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.The semantic integration of geographically distributed and heterogeneous data resources still remains a key challenge in Grid infrastructures. Today's
Naseer, Aisha
core  

Fabrication of porous metallic glass using a dissolution manufacturing strategy and their functional applications

Materials Today Advances
Recent developments in the engineering of metallic glasses (MGs) with custom properties have been compelling, particularly in porous constructions.
Junsheng Liu, Wenqing Ruan, Jianan Fu, Heting Zhang, Shenghao Zeng, Shuai Ren, Jiang Ma   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Advanced Sensor Systems by Low-Temperature Heterogeneous 3D Integration Processes

, 2018
A few application demonstrators of heterogeneous 3D integrated systems including innovative nanosensors for gas detection and biofludic applications have been successfully implemented showing efficient low-temperature heterogeneous integration processes,
Peter Ramm, Muller, Andrei, Fernandez-Bolanos, Montserrat, Ramm, Peter, Josef Weber, Andrei Muller, Weber, Josef, Montserrat Fernandez-Bolanos   +7 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source