Results 171 to 180 of about 39,672 (250)

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

open access: yesAdvanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai   +4 more
wiley   +1 more source

DyProL: Dynamic Ensemble Representation Learning for Protein–Nucleic Acid Binding Site Prediction

open access: yesAdvanced Science, EarlyView.
Protein function is represented as a dynamic conformational ensemble rather than a single static structure. A multi‐conformation geometric attention framework aligns, clusters, and learns representative states to capture residue‐ and ensemble‐level signals. Integrating structural dynamics improves interpretable protein‐NA binding prediction and reveals
Pengpai Li   +3 more
wiley   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin   +10 more
wiley   +1 more source

A Preclinical Multifunctional Capsule Robot with Unified Diagnosis and Targeted Thermal Therapy for Gastrointestinal Diseases

open access: yesAdvanced Science, EarlyView.
A proof‐of‐concept multifunctional capsule robot integrates diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy for gastrointestinal applications. Magnetically guided positioning and stable wireless power enable localized thermal ablation, achieving controlled heating and high cell mortality in vitro.
Heng Zhang   +7 more
wiley   +1 more source

MXene‐Based Room‐Temperature NO2 Gas Sensors: A Meta‐Analysis

open access: yesAdvanced Science, EarlyView.
This study presents the first comprehensive meta‐analysis of MXene‐based NO2 sensors, decoding 32 study characteristics across 61 peer‐reviewed studies. By isolating materials chemistry as the primary performance driver over device‐level parameters, the authors establish a methodological blueprint and a predictive structure–function map to accelerate ...
Alexander Khort   +3 more
wiley   +1 more source

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