Results 111 to 120 of about 4,457,878 (308)
Heterogeneous Genetic Learning and Comprehensive Learning Strategy Particle Swarm Optimizer
AlgorithmsIn canonical PSO, maintaining an appropriate balance between exploration and exploitation is vital for optimizing particle behavior. However, this balance can be difficult to achieve in some complex scenarios. To tackle this issue, this study proposes an
Shengliang Wang, Yuqing Li, Yao Li
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Research on High-Reliability Energy-Aware Scheduling Strategy for Heterogeneous Distributed Systems
Big Data and Cognitive ComputingWith the demand for workflow processing driven by edge computing in the Internet of Things (IoT) and cloud computing growing at an exponential rate, task scheduling in heterogeneous distributed systems has become a key challenge to meet real-time ...
Ziyu Chen, Jing Wu, Lin Cheng, Tao Tao
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 2015 To assist in the development of the National Diabetes Strategy, the Federal Government has released this consultation paper and invites submissions from the public. Purpose This document has been written by the National Diabetes Strategy Advisory Group
National Diabetes Strategy Advisory Group
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Nyeri County Fiscal Strategy Paper 2015 [PDF]
, 2015 The preparation of the CFSP, 2015 is a collaborative effort of the county departments with overall coordination by the Finance and Economic Planning department.
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3 GPa dual-phase stainless steel from synergistic heterogeneous structure and nano-precipitate
Materials Research LettersGrain refinement is the most common strategy to improve the mechanical performance of metals such as strength, wear resistance and fatigue. For the 2101 duplex stainless steel (DSS), a heterogeneous microstructure composed of sub-25 nm fiber grains and ...
Qiang Li +7 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
National Cancer Control Strategy 2017-2022
, 2017 The overall goal of the Kenya Health Sector Referral Strategy is to improve client access to referral. The objectives of the strategy are to realise improved capacity of health providers to identify clients who require referral, develop protocols that ...
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