Results 41 to 50 of about 123,795 (300)

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Assessing the danger of self-sustained HIV epidemics in heterosexuals by population based phylogenetic cluster analysis

eLife, 2017
Assessing the danger of transition of HIV transmission from a concentrated to a generalized epidemic is of major importance for public health. In this study, we develop a phylogeny-based statistical approach to address this question.
Teja Turk, Nadine Bachmann, Claus Kadelka, Jürg Böni, Sabine Yerly, Vincent Aubert, Thomas Klimkait, Manuel Battegay, Enos Bernasconi, Alexandra Calmy, Matthias Cavassini, Hansjakob Furrer, Matthias Hoffmann, Huldrych F Günthard, Roger D Kouyos, Swiss HIV Cohort Study   +15 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Sexual behaviour in Britain: early heterosexual experience.

, 2001
BACKGROUND: Relatively high rates of teenage conception and sexually transmitted infection among young people in Britain have focused attention on early sexual behaviour and its determinants.
Nanchahal, K, McManus, S, Erens, B, Korovessis, C, Macdowall, W, Mercer, CH, Field, J, Copas, AJ, Wellings, K, Fenton, KA, Johnson, AM, Kaye Wellings, Catherine H Mercer, Anne M Johnson, Kevin A Fenton, Wendy Macdowall, Bob Erens, Sally McManus, Kiran Nanchahal, Andrew J Copas, Julia Field, Christos Korovessis   +21 more
core   +1 more source

Ruptures in the heterosexual matrix through teenage flows and multiplicities [PDF]

, 2013
This article analyzes a series of stories and artworks that were produced in a collective biography workshop. It explores Judith Butler’s concept of the heterosexual matrix combined with a Deleuzian theoretical framework.
Gonick, Marnina, Gottschall, Kristina, Lampert, Jo, Davis, Bronwyn   +3 more
core   +2 more sources

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Expectations for family building, assisted reproduction, and adoption among lesbians in the National Survey of Family Growth, 2017–2019

F&S Reports, 2023
Objective: To characterize the family-building goals and experiences of lesbians compared with those of heterosexual females in the United States. Design: Secondary analysis of nationally representative, cross-sectional survey data.
Caroline J. Violette, M.D., Brian T. Nguyen, M.D., M.Sc.   +1 more
doaj   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Factors associated with heterosexual transmission of HIV to individuals without a major risk within England, Wales, and Northern Ireland: a comparison with national probability surveys [PDF]

, 2006
Objective: To compare the prevalence of HIV risk behaviours reported by heterosexuals without major risks for HIV acquisition diagnosed with HIV in England, Wales, and Northern Ireland, with those of the heterosexual general population.Methods ...
Dougan, S, Mercer, CH, Copas, AJ, Evans, BG, Fenton, KA, Johnson, AM, Gilbart, VL   +6 more
core  

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

Advanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares, Nadège Bouchonneau, Christian Jochum, Donald Radford   +3 more
wiley   +1 more source