Results 141 to 150 of about 4,489 (232)

Sustained Effector Functions and Memory Accumulation of αβ T Cells in Children With Congenital Heart Disease

European Journal of Immunology, Volume 56, Issue 5, May 2026.
This study showed dysregulated αβ T cell homeostasis with ongoing T cell activation and low‐grade inflammation in 5‐12‐year‐old CHD children who underwent early‐life cardiac surgery with thymectomy, characterized by reduced naïve T cells and increased memory/effector and senescent‐like T cells.
Yusuf Eshimutu Abu, Christoph Kammeyer, Tao Yang, Rodrigo Gutierrez Jauregui, Alexa Cramer, Claudia Junge, Svea Kleiner, Anika Janssen, Adan Chari Jirmo, Alexander Horke, Reinhold Förster, Philipp Beerbaum, Martin Boehne, Sarina Ravens   +13 more
wiley   +1 more source

Secondary Colonic Adenocarcinoma After Continent Cutaneous Urinary Diversion a.m. Lundiana—An Aggressive Disease Entity With High Risk of Locally Advanced Disease and Metastases

IJU Case Reports, Volume 9, Issue 3, May 2026.
ABSTRACT Introduction We herein report two patients developing secondary adenocarcinomas arising in colonic segments used for urinary diversion a.m. Lundiana in a population‐based series 16 and 27 years after cystectomy, respectively. Case Presentation Following initial partial resection of the pouch, both patients experienced local recurrence; one ...
Fredrik Liedberg, Mats Bläckberg, Johannes Bobjer   +2 more
wiley   +1 more source

Ivemark syndrome in an adult with complete atrioventricular septal defect and a single ventricle with L-transposition of the great arteries: a case report

Journal of Medical Case Reports
Background Ivemark syndrome is a rare heterotaxy disorder characterized by right atrial isomerism, complex congenital heart defects, and thoraco-abdominal anomalies. Because of such defects, survival beyond infancy is rare.
Hind Hibatouallah, Samah El-Mhadi, Selma Siagh, Zakia Touati, Mohamed Cherti   +4 more
doaj   +1 more source

Most costly and prevalent reasons for hospitalization in children with medical complexity in Ontario, Canada

Journal of Hospital Medicine, Volume 21, Issue 5, Page 495-505, May 2026.
Abstract Background and Objectives Children with medical complexity (CMC) have chronic health conditions often associated with functional limitations. CMC comprise 1%–5% of the pediatric population. In Canada, their care accounts for one‐third of pediatric health spending.
Erin Hessey, Thaksha Thavam, Sanjay Mahant, Eyal Cohen, Jingqin Zhu, Francine Buchanan, Teresa To, Peter J. Gill, Ontario Pediatric Hospital Care Study Group (OPHCSG) and the Canadian Paediatric Inpatient Research Network (PIRN), Wenjia Chen, Ronald Cohn, Mairead Green, Matt Hall, Kate Langrish, Colin Macarthur, Myla Moretti, Patricia Parkin, Michelle Quinlan, Ann Bayliss, Ronik Kanani, Sean Murray, Catherine Pound, Mahmoud Sakran, Anupam Sehgal, Sepi Taheri, Gita Wahi   +25 more
wiley   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 780-818, May 2026.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

NONO‐Related Syndromic X‐Linked Developmental Disability 34: Further Clinical and Molecular Delineation in a Prenatal Cohort

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 914-923, May 2026.
ABSTRACT Objective To characterize the prenatal sonographic features across different trimesters and genomic spectrum of NONO‐related X‐linked intellectual developmental disorder. Method We analyzed two fetuses presenting with corpus callosum agenesis and rare cardiac anomalies using genome sequencing and exome sequencing.
Yilin Zhao, Gang Zou, Mengmeng Shi, Kwok Ming Law, So Ling Lau, Meng Meng, Yuen Ha Ting, Chiu Yee Liona Poon, Zirui Dong, Matthew Hoi Kin Chau, Tak Yeung Leung, Kwong Wai Choy, Xinwen Zhang, Ye Cao   +13 more
wiley   +1 more source

A Rare Syndromic Coexistence: Bilateral Duplicated Collecting Systems with Bilateral Ureterovesical Junction Obstruction in a Child with Heterotaxy Syndrome and Polysplenia: A Case Report

Dr. Sulaiman Al Habib Medical Journal
The simultaneous occurrence of bilateral duplicated collecting systems and heterotaxy syndrome is extremely rare, with no previously reported cases from our setting to our knowledge.
Zubeir Zubeir, Zuhura Nkrumbih, Gerald Mpemba   +2 more
doaj   +1 more source

Patella baja post tibial plateau levelling osteotomy on a 7‐year‐old Bichon Frise

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 7‐year‐old, male, neutered Bichon Frise presented with a 3‐month history of intermittent lameness 18 months post tibial plateau levelling osteotomy as treatment for cranial cruciate ligament rupture. On the physical examination, hyperextension of the right stifle joint was detected.
Georgios Vlachomitros, Mark Alexander Bush   +1 more
wiley   +1 more source

Heart Rate Variability in Newborns From Diabetic Mothers: Clinical Application and Significance

Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
Risk factors for GDM contribute to a hyperglycemic intrauterine environment, which may in turn impair ANS function in the offspring. Altered ANS activity can be assessed through measures such as HRV. ABSTRACT Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, arising from inadequate insulin secretion and increased ...
Virginia Beretta, Laura Cannavò, Sebastiano Ravenda, Chiara Petrolini, Vincenzo Raitano, Sabrina Moretti, Valentina Dell'Orto, Serafina Perrone   +7 more
wiley   +1 more source