Results 51 to 60 of about 4,442 (232)

Tracheostomy Following Surgery for Congenital Heart Disease: 14-year Institutional Experience [PDF]

, 2016
Background: Tracheostomy following congenital heart disease (CHD) surgery is a rare event and associated with significant mortality. Hospital survival has been reported from 20% to 40%.
Ackerman, Veda, Benneyworth, Brian D., Brown, John W., Cristea, A. Ioana, Rodefeld, Mark D., Shao, Jenny M., Turrentine, Mark W.   +6 more
core   +1 more source

Classifying Heterotaxy Syndrome [PDF]

Circulation: Cardiovascular Imaging, 2018
Heterotaxy syndrome is a complex set of abnormalities related to abnormal left–right axis patterning. Although rare (occurring in just over 1 in 10 000 live births1), congenital heart defects associated with heterotaxy syndrome carry a disproportionate burden of morbidity and mortality.2,3 Despite numerous investigations on the genetic underpinning ...
Stephen P, Sanders, Tal, Geva
openaire   +2 more sources

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Heterotaxy polysplenia syndrome with cholangiopancreatic cancer: a case report and literature review

Frontiers in Medicine
BackgroundHeterotaxy polysplenia syndrome is a rare condition characterized by multiple abnormal spleens and irregular placement of various organs. Some patients have been documented as developing various types of cancers, although the association with ...
Ziye Chen, Ziye Chen, Yu-Ann Chen, Yu-Ann Chen, Xuedong Wang, Wenyan Song, Wenyan Song, Yadi Geng, Yadi Geng, Pengfei Wang, Siming Kong, Jiahong Dong, Jiahong Dong, Hui Bai, Yunfang Wang, Yunfang Wang, Yunfang Wang, Yunfang Wang   +17 more
doaj   +1 more source

Heterotaxy syndrome with intestinal malrotation, polysplenia and azygos continuity

Clinics and Practice, 2018
Heterotaxy syndrome is a situs anomaly that comprises a large spectrum of cardiac and extracardiac malformations. Its association with intestinal malrotation is frequent. This later might be asymptomatic or manifest by signs of abdominal discomfort or of
Stéphanie Cupers, Christine Van Linthout, Brigitte Desprechins, Léon Rausin, Martine Demarche, Marie-Christine Seghaye   +5 more
doaj   +1 more source

Anatomy, embryology, and imaging of situs ambiguous with polysplenia and left IVC

Radiology Case Reports, 2023
The situs ambiguous or heterotaxy syndrome is a type of syndrome that involves multiple visceral abnormalities, vascular ones and associated with left isomerism.
Rosa Montero-Macías, MD, David Krief, MD, Vincent Villefranque, MD, Mohamed Kilani, MD, Juan Manuel Castillo-Tuñon, MD, PhD   +4 more
doaj   +1 more source

Coronary steal syndrome after coronary artery bypass for anomalous aortic origin of a coronary artery. [PDF]

, 2009
Anomalous aortic origin of a coronary artery found in a symptomatic 9-year-old boy was initially treated with coronary artery bypass grafting using a left internal mammary artery anastomoses to the left anterior descending coronary artery, but resulted ...
Jacobs, Marshall L, Mesia, C Igor, Pelletier, Glenn J, Youdelman, Benjamin A   +3 more
core   +2 more sources

Implementation of First‐Line Rapid Genome Sequencing for Children in Pediatric and Cardiac Intensive Care Units

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Substantial data supports the use of rapid exome and genome sequencing (rES/rGS) in Neonatal Intensive Care Units (NICU), but fewer studies have examined the impact of rES/rGS in other pediatric critical care units. We evaluated the impact on diagnostic yield and time to diagnosis following a single‐center hospital policy change allowing ...
Alexandra C. Keefe, Abbey A. Scott, Lukas Kruidenier, Jessie Conta, Darci L. Sternen, Sarah V. Clowes Candadai, Shannon M. Stasi, Julia Parish‐Morris, Megan Sikes, Margaret P. Adam, Anita E. Beck, Jennifer C. Hayek, Ian Glass, James T. Bennett, Ghayda Mirzaa, Paul Kruszka, Britt Johnson, Kirsty McWalter, Deborah Copenheaver, Bethany Friedman, Michael Bamshad, Katrina M. Dipple, Tara L. Wenger   +22 more
wiley   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Genetics and Genetic Testing in Congenital Heart Disease [PDF]

, 2015
Congenital heart defects (CHDs) are structural abnormalities of the heart and great vessels that are present from birth. The presence or absence of extra-cardiac anomalies has historically been used to identify patients with possible monogenic ...
Cowan, Jason R., Ware, Stephanie M.
core   +1 more source