Heterozygote advantage for fecundity. [PDF]
PLoS ONE, 2006 Heterozygote advantage, or overdominance, remains a popular and persuasive explanation for the maintenance of genetic variation in natural populations in the face of selection.
Neil J Gemmell, Jon Slate
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Heterozygote Advantage Probably Maintains Rhesus Factor Blood Group Polymorphism: Ecological Regression Study. [PDF]
PLoS ONE, 2016 Rhesus factor polymorphism has been an evolutionary enigma since its discovery in 1939. Carriers of the rarer allele should be eliminated by selection against Rhesus positive children born to Rhesus negative mothers.
Jaroslav Flegr
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Heterozygote advantage at HLA class I and II loci and reduced risk of colorectal cancer [PDF]
Frontiers in Immunology, 2023 ObjectiveReduced diversity at Human Leukocyte Antigen (HLA) loci may adversely affect the host’s ability to recognize tumor neoantigens and subsequently increase disease burden. We hypothesized that increased heterozygosity at HLA loci is associated with
Ya-Yu Tsai +29 more
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The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia [PDF]
Haematologica, 2011 The germ-line loss-of-function VHLR200W mutation is common in Chuvashia, Russia and occurs in other parts of the world. VHLR200W homozygotes have elevated hypoxia inducible factor (HIF)-1 and HIF-2 levels, increased hemoglobin concentration, propensity ...
Galina Y. Miasnikova +8 more
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Heterozygote advantage can explain the extraordinary diversity of immune genes [PDF]
eLife, 2018 The majority of highly polymorphic genes are related to immune functions and with over 100 alleles within a population, genes of the major histocompatibility complex (MHC) are the most polymorphic loci in vertebrates.
Mattias Siljestam, Claus Rueffler
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Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19. [PDF]
J Clin Endocrinol Metab, 2022 Context The type 2 deiodinase and its Thr92Ala-DIO2 polymorphism have been linked to clinical outcomes in acute lung injury and pulmonary fibrosis. Objective Our objectives were to evaluate were cumulative mortality during admission according to Thr92Ala-
de Lima Beltrão FE +16 more
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Heterozygote advantage and pleiotropy contribute to intraspecific color trait variability. [PDF]
Evolution, 2022 The persistence of intrapopulation phenotypic variation typically requires some form of balancing selection because drift and directional selection eventually erode genetic variation.
De Pasqual C +5 more
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Heterozygote Advantage of the rs3794624 Polymorphism in CYBA for Resistance to Tuberculosis in Two Chinese Populations. [PDF]
Sci Rep, 2016 Phagocyte Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase complex is a key enzyme that catalyzes the production of reactive oxygen species, which mediate oxygen-dependent killing of microorganisms, such as Mycobacterium tuberculosis. P22phox,
Liu Q +11 more
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Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans [PDF]
BMC Genetics, 2019 Background Genetic diversity is known to confer survival advantage in many species across the tree of life. Here, we hypothesize that such pattern applies to humans as well and could be a result of higher fitness in individuals with higher genomic ...
Ke Xu +9 more
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Overdominance effect of the bovine ghrelin receptor (GHSR1a)-DelR242 locus on growth in Japanese Shorthorn weaner bulls: heterozygote advantage in bull selection and molecular mechanisms. [PDF]
G3 (Bethesda), 2014 Ghrelin and the ghrelin receptor (GHSR1a) are involved in growth hormone secretion, food intake, and several other important functions. Ghrelin acts on GHSR1a and induces signal transduction via the Gαq subunit.
Komatsu M +11 more
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