Results 111 to 120 of about 3,081,667 (237)

Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage. [PDF]

, 2019
One fundamental but understudied mechanism of gene regulation in disease is allele-specific expression (ASE), the preferential expression of one allele.
A Chess, A de la Chapelle, A Gimelbrant, A Hogart, A McKenna, A Mortazavi, AA Adegbola, AL Oberg, AM Veerappa, B DeVeale, B Howie, B Langmead, B Tycko, C Fuchsberger, C Gicquel, C Gregg, C Lee, CA de Leeuw, CCY Wong, Changhoon Lee, Cross-Disorder Group of the Psychiatric Genomics Consortium., D Kim, Daniel H. Geschwind, DH Geschwind, E Ben-David, E Eden, E Eden, E Gardiner, EH Cook Jr., Eleazar Eskin, EM Quinn, Eun Yong Kang, EY Kang, F Supek, GT Consortium, GV Kryukov, H Li, HA Scoles, I Iossifov, I Voineagu, J Cavaille, J Cavaille, J Grove, JC Darnell, JF Degner, JK Pickrell, KR Kukurba, M Elsabbagh, M Meguro-Horike, Michael J. Gandal, N Mukherjee, NN Parikshak, NN Parikshak, PH Sudmant, PS Bazeley, R Karlic, S Anders, S Kehr, S Kishore, S Nardone, S Purcell, Schizophrenia Working Group of the Psychiatric Genomics Consortium., SE Castel, SJ Sanders, SM Weyn-Vanhentenryck, T Hulsen, V Savova, Y Zhang, YE Wu   +68 more
core   +1 more source

Making Molecular Diagnostics Faster

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Over the past 40 years, molecular diagnostic methods have evolved from multi‐step, time‐consuming protocols towards either rapid targeted tests or expansive, massively parallel testing. Aims Here we consider the speed limits of targeted molecular diagnostics, considering the three sequential required steps: nucleic acid preparation,
Carl T. Wittwer, Luming Zhou, Felix Ye, Adam Millington, Adrian de Cola, Noriko Kusukawa   +5 more
wiley   +1 more source

VAL34LEU POLYMORPHISM DETECTION BY REAL TIME PCR ASSAY USING FLUORESCENCE RESONANCE ENERGY TRANSFER ON ROTOR-GENE 6000

International Journal of Health Services Research and Policy, 2016
Factor XIII (FXIII) Val34Leu is the most important polymorphism of the A subunit in factor XIII gene. The aim of the present study was to develop an efficient method based on real time PCR with Fluorescence resonance energy transfer (FRET) detection ...
Maryam NASER KAMJOO, Ali NAZEMI
doaj   +1 more source

Genomic Analysis of Taurine and Indicine Ancestry in the Montana Tropical Composite Population

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The Montana Tropical cattle, a Taurine and Indicine composite, were developed in Brazil since 1994 and were based on crossing four biological types of cattle: zebu (mainly Nelore), tropical adapted taurine (mainly Senepol and Romosinuano), British taurine (mainly Angus) and continental taurine (as Charolais, Simental and Limousin).
Camila Alves dos Santos, El Hamidi Hay, Elisangela Chicaroni de Mattos Oliveira, Rafael Espigolan, José Bento Sterman Ferraz, Tiago do Prado Paim   +5 more
wiley   +1 more source

Comprehensive evaluation of SNP identification with the Restriction Enzyme-based Reduced Representation Library (RRL) method

BMC Genomics, 2012
Background Restriction Enzyme-based Reduced Representation Library (RRL) method represents a relatively feasible and flexible strategy used for Single Nucleotide Polymorphism (SNP) identification in different species.
Du Ye, Jiang Hui, Chen Ying, Li Cong, Zhao Meiru, Wu Jinghua, Qiu Yong, Li Qibin, Zhang Xiuqing   +8 more
doaj   +1 more source

Evolution of population with sexual and asexual reproduction in changing environment

, 2003
Using a lattice model based on Monte Carlo simulations, we study the role of the reproduction pattern on the fate of an evolving population. Each individual is under the selection pressure from the environment and random mutations. The habitat ("climate")
CHANGLIANG YU, Fraser A., HONGBO RUAN, LEI YAO, MINGFENG HE, Muller H. J., Orcal B., Penna T. J. P., Wachter K. W.   +8 more
core   +1 more source

A novel approach to simulate gene-environment interactions in complex diseases [PDF]

, 2009
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc ...
A Carvajal-Rodriguez, B Peng, C Li, Consortium TWTCC, D Gasbarra, Daniel D'Andrea, DE Weeks, DJ Hunter, DW Hosmer, Gennaro Miele, Giancarlo Raiconi, Group TGCR, J Haldane, J Hoh, J Ott, JD Terwilliger, KE Lohmueller, LM Ploughman, LW Hahn, M Boehnke, M Garcia-Closas, M Schmidt, Mario Nicodemi, MD Ritchie, Michele Pinelli, MJ Khoury, NM Laird, Roberto Amato, Sergio Cocozza, SM Leal, WJ Gauderman, Y Murase   +31 more
core   +6 more sources

Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez, C. Hervás‐Rivero, R. Rodríguez‐Bermúdez, D. López‐Carbonell, M. Hermida, P. Martínez, L. Varona   +6 more
wiley   +1 more source

A single nucleotide polymorphism genotyping panel for efficient genetic stock identification of the Teno river Atlantic salmon (Salmo salar) population complex

Journal of Fish Biology, EarlyView.
Abstract A new single nucleotide polymorphism (SNP) panel for genetic stock identification in the Teno river Atlantic salmon, Salmo salar L., fishery was developed, with a view to improving on an existing microsatellite panel. Twenty‐two genetically differentiated reporting units were proposed based on population genetic analyses of 1212 individuals ...
Helena Johansson, Jaakko Erkinaro, Morten Falkegård, Anders Foldvik, Panu Orell, Craig R. Primmer, Victoria L. Pritchard   +6 more
wiley   +1 more source

Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis [PDF]

, 2015
Evolution of the breast cancer genome from pre-invasive stages to asynchronous metastasis is complex and mostly unexplored, but highly demanded as it may provide novel markers for and mechanistic insights in cancer progression.
Bak, Martin, Jensen, Jeanette Dupont, Knoop, Ann, Kruse, Torben A, Krøigård, Anne Bruun, Larsen, Martin Jakob, Lænkholm, Anne Vibeke, Mollenhauer, Jan, Thomassen, Mads   +8 more
core   +3 more sources