FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study. [PDF]
PLoS ONE, 2015 Single nucleotide polymorphisms (SNPs) within the Fat mass and obesity associated (FTO) gene have been linked with increased body weight. However, the data on an association of FTO with cardiovascular diseases remains conflicting.
Cindy Thron +5 more
doaj +3 more sources
Heterozygote Advantage Is a Common Outcome of Adaptation in Saccharomyces cerevisiae. [PDF]
Genetics, 2016 Sellis D +4 more
europepmc +4 more sources
G6PD deficiency: a polymorphism balanced by heterozygote advantage against malaria. [PDF]
The Lancet Haematology, 2015 n ...
L. Luzzatto
semanticscholar +5 more sources
Parasite-mediated heterozygote advantage in an outbred songbird population. [PDF]
Biol Lett, 2005 Coevolution with parasites is thought to maintain genetic diversity in host populations. However, while there are sound theoretical reasons to expect heterozygosity and parasite resistance to be related, this pattern has generally been shown only in inbred laboratory and island populations.
MacDougall-Shackleton EA +4 more
europepmc +5 more sources
Heterozygote advantage as a natural consequence of adaptation in diploids. [PDF]
Proc Natl Acad Sci U S A, 2011 Molecular adaptation is typically assumed to proceed by sequential fixation of beneficial mutations. In diploids, this picture presupposes that for most adaptive mutations, the homozygotes have a higher fitness than the heterozygotes. Here, we show that contrary to this expectation, a substantial proportion of adaptive mutations should display ...
Sellis D +3 more
europepmc +5 more sources
Heterozygote advantage for the phenylketonuria allele. [PDF]
Journal of Medical Genetics, 1977 Mean weight at birth of unaffected (normal homozygous and PKU heterozygous) offspring of parents heterozygous for the phenylketonuria (PKU) allele averages significantly above that of Norwegian neonates, with no significant difference in mean age of mothers or in mean parity. It approaches the optimal birthweight--that which confers the minimum overall
L. Saugstad
semanticscholar +7 more sources
Connexin 26 variant carriers have a better gastrointestinal health: is this the heterozygote advantage? [PDF]
Eur J Hum Genet, 2014 Vuckovic D +5 more
europepmc +4 more sources
Interrogating the Roles of Mutation-Selection Balance, Heterozygote Advantage, and Linked Selection in Maintaining Recessive Lethal Variation in Natural Populations. [PDF]
Annual Review of Animal Biosciences, 2022 For nearly a century, evolutionary biologists have observed chromosomes that cause lethality when made homozygous persisting at surprisingly high frequencies (>25%) in natural populations of many species.
Sarah B. Marion, M. Noor
semanticscholar +2 more sources
HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation. [PDF]
Mol Biol Evol, 2020 Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the heterozygote advantage at genes of the human leukocyte antigen (HLA), resulting in improved HIV-1 ...
Arora J +5 more
europepmc +2 more sources
MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques. [PDF]
Sci Transl Med, 2010 O'Connor SL +19 more
europepmc +3 more sources