Results 201 to 210 of about 3,081,667 (237)

What is the evidence for heterozygote advantage selection?

Trends in Ecology & Evolution, 2012
Recent genomic data have found that many genes show the signal of selection. How many of these genes are undergoing heterozygote advantage selection is only beginning to be known. Initial genomic surveys have suggested that only a small proportion of loci have polymorphisms maintained by heterozygote advantage and this is consistent with the few ...
P. Hedrick
semanticscholar   +3 more sources

Bovine major histocompatibility complex (BoLA) heterozygote advantage against the outcome of bovine leukemia virus infection

HLA, 2021
Bovine leukemia virus (BLV) causes enzootic bovine leucosis. Host genetic heterozygosity at the major histocompatibility complex can enhance the ability to combat infectious diseases.
Chieh-Wen Lo, S. Takeshima, S. Wada, Y. Matsumoto, Y. Aida   +4 more
semanticscholar   +1 more source

Selective advantage of fra (X) heterozygotes

Human Genetics, 1990
The high incidence of the fra (X) syndrome (about 1:2000 male newborns) requires an explanation in view of the low fitness of mentally retarded hemizygous males and heterozygous females. In the past, it has been proposed that the mutation rate may be unusually high, and that mutations occur exclusively in male germ cells.
F, Vogel, W E, Crusio, C, Kovac, J P, Fryns, M, Freund   +4 more
openaire   +2 more sources

Heterozygote advantage in cystic fibrosis: mosquito tests

Clinical Genetics, 1979
Tests to demonstrate a preference by mosquitoes for stinging controls as opposed to obligate heterozygotes for Cystic Fibrosis proved negative. If a heterozygote advantage caused a lower malarial incidence in carriers in South West Africa, it must have worked through the malarial parasite being adversely affected by a serum factor.
M, Super, D J, van Schalkwyk
openaire   +2 more sources

The cystic fibrosis heterozygote — Advantage in surviving cholera?

Medical Hypotheses, 1991
Cystic fibrosis (CF) is the most common fatal genetic disorder of caucasians. While it has been hypothesized that there is a CF heterozygote advantage which allowed the gene to achieve such high prevalence, the nature of that advantage remains a mystery.
D M, Rodman, S, Zamudio
openaire   +2 more sources

Hypothesis: A selective advantage for cystic fibrosis heterozygotes

American Journal of Physical Anthropology, 1987
AbstractEuropean populations have both a particularly long history of pulmonary tuberculosis and extremely high frequencies of cystic fibrosis (CF). While carriers of the recessive gene are asymptomatic for CF disease, their fibroblasts produce excessive amounts of hyaluronic acid, whose role in successful isolation of virulent pathogens appears to be ...
openaire   +2 more sources

Myocardial infarction and thalassemia trait: An example of heterozygote advantage

American Journal of Hematology, 1995
AbstractThis study was designed to test the hypothesis that thalassemia trait diminishes the likelihood of myocardial infarction. If the hypothesis is true the prevalence of thalassemia trait should be less in myocardial infarct patients than in a control population.
C H, Wang, R F, Schilling
openaire   +2 more sources

Heterozygote advantage in the American chestnut, Castanea dentata (Fagaceae)

American Journal of Botany, 2003
The American chestnut (Castanea dentata; Fagaceae) was a dominant canopy tree in the Appalachian Mountains of North America. Since the introduction of the chestnut blight fungus (Cryphonectria parasitica; Valsaceae) in America, the American chestnut has been reduced to a predominantly clonal, understory species.
Kevin L, Stilwell, Henry M, Wilbur, Charles R, Werth, Douglas R, Taylor   +3 more
openaire   +2 more sources

Heterozygote advantage in Tay-Sachs carriers?

American journal of human genetics, 1981
Chi-square analyses of new data as well as data previously reported by Myrianthopoulos have shown that grandparents of Tay-Sachs carriers die from proportionally the same causes as grandparents of noncarriers. It is unlikely that there is any advantage to being a Tay-Sachs carrier insofar as resistance to tuberculosis is concerned.
B, Spyropoulos, P B, Moens, J, Davidson, J A, Lowden   +3 more
openaire   +1 more source

Heterozygous advantage and its relationship to increased heterozygote fertility

Annals of Human Genetics, 1968
8. SUMMARYA simple model has been discussed which takes into account variable family sizes. It has been shown that these greatly influence the equilibrium gene and trait frequencies in a population of births, for a lethal recessive autosomal gene.
openaire   +2 more sources