Evolution and genetic architecture of disassortative mating at a locus under heterozygote advantage [PDF]
bioRxiv, 2019 The evolution of mate preferences may depend on natural selection acting on the mating cues and on the underlying genetic architecture. While the evolution of assortative mating with respect to locally adapted traits has been well-characterized, the ...
Ludovic Maisonneuve +3 more
semanticscholar +2 more sources
A preliminary study of genetic factors that influence susceptibility to bovine tuberculosis in the British cattle herd. [PDF]
PLoS ONE, 2011 Associations between specific host genes and susceptibility to Mycobacterial infections such as tuberculosis have been reported in several species. Bovine tuberculosis (bTB) impacts greatly the UK cattle industry, yet genetic predispositions have yet to ...
Erin E Driscoll +4 more
doaj +26 more sources
The course of malaria in mice: major histocompatibility complex (MHC) effects, but no general MHC heterozygote advantage in single-strain infections. [PDF]
Genetics, 2005 Wedekind C, Walker M, Little TJ.
europepmc +4 more sources
Do ΔF508 heterozygotes have a selective advantage? [PDF]
Genetical Research, 2001 In this paper the fitness of the ΔF508 heterozygote is assessed and the age of the ΔF508 mutation in the cystic fibrosis locus is estimated. Data from three microsatellite loci are applied. The analysis is performed conditional on the present-day frequency of the ΔF508 mutation and based on assumptions about the demographic history of the European ...
Carsten Wiuf
openalex +4 more sources
Heterozygote advantage can explain the extraordinary diversity of immune genes [PDF]
bioRxiv, 2018 The majority of highly polymorphic genes are related to immune functions and with over 100 alleles within a population, genes of the major histocompatibility complex (MHC) are the most polymorphic loci in vertebrates.
Mattias Siljestam, C. Rueffler
semanticscholar +2 more sources
Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage [PDF]
Abstract Several theoretical studies have concluded that heterozygote advantage makes at most a minor contribution to MHC diversity. Siljestam and Rueffler (2024) recently presented models in which heterozygote advantage alone can lead to realistically high diversity.
Joshua L. Cherry
+4 more sources
HLA Genetic Diversity and Chronic Hepatitis B Virus Infection: Effect of Heterozygosity Advantage [PDF]
Medical SciencesThis research aims to determine whether HLA heterozygosity confers a protective effect against hepatitis B virus infection by analyzing the relationship between HLA diversity and the risk of hepatitis B virus (HBV) infection.
Adriana Tălăngescu +5 more
doaj +2 more sources
Choosy Wolves? Heterozygote Advantage But No Evidence of MHC-Based Disassortative Mating. [PDF]
J Hered, 2016 Galaverni M +5 more
europepmc +2 more sources
Adaptive meiotic drive in selfing populations with heterozygote advantage [PDF]
Theoretical Population Biology, 2019 AbstractThe egalitarian allotment of gametes to each allele at a locus (Mendel’s law of segregation) is a near-universal phenomenon characterizing inheritance in sexual populations. As exceptions to Mendel’s law are known to occur, one can investigate why non-Mendelian segregation is not more common using modifier theory.
Evgeny Brud
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