An asymmetric model of heterozygote advantage at major histocompatibility complex genes: degenerate pathogen recognition and intersection advantage. [PDF]
Genetics, 2008 Stoffels RJ, Spencer HG.
europepmc +2 more sources
Red Queen Processes Drive Positive Selection on Major Histocompatibility Complex (MHC) Genes. [PDF]
PLoS Computational Biology, 2015 Major Histocompatibility Complex (MHC) genes code for proteins involved in the incitation of the adaptive immune response in vertebrates, which is achieved through binding oligopeptides (antigens) of pathogenic origin.
Maciej Jan Ejsmond, Jacek Radwan
doaj +1 more source
The heterozygote superiority hypothesis for polymorphic color vision is not supported by long-term fitness data from wild neotropical monkeys. [PDF]
PLoS ONE, 2014 The leading explanatory model for the widespread occurrence of color vision polymorphism in Neotropical primates is the heterozygote superiority hypothesis, which postulates that trichromatic individuals have a fitness advantage over other phenotypes ...
Linda M Fedigan +3 more
doaj +1 more source
Frontiers in Immunology, 2021 The high polymorphism of Major Histocompatibility Complex (MHC) genes is generally considered to be a result of pathogen-mediated balancing selection. Such selection may operate in the form of heterozygote advantage, and/or through specific MHC allele ...
Kristin Scherman +2 more
doaj +1 more source
Hardy-Weinberg Equilibrium in the Large Scale Genomic Sequencing Era
Frontiers in Genetics, 2020 Hardy-Weinberg Equilibrium (HWE) is used to estimate the number of homozygous and heterozygous variant carriers based on its allele frequency in populations that are not evolving. Deviations from HWE in large population databases have been used to detect
Nikita Abramovs +5 more
doaj +1 more source
Evolutionary ecology of opsin gene sequence, expression and repertoire. [PDF]
, 2017 Linking molecular evolution to biological function is a long-standing challenge in evolutionary biology. Some of the best examples of this involve opsins, the genes that encode the molecular basis of light reception.
Owens, Gregory L, Rennison, Diana J
core +1 more source
MHC allele frequency distributions under parasite-driven selection: A simulation model
BMC Evolutionary Biology, 2010 Background The extreme polymorphism that is observed in major histocompatibility complex (MHC) genes, which code for proteins involved in recognition of non-self oligopeptides, is thought to result from a pressure exerted by parasites because parasite ...
Radwan Jacek +2 more
doaj +1 more source
Gene dynamics of toll-like receptor 4 through a population bottleneck in an insular population of water voles (Arvicola amphibius) [PDF]
, 2015 Acknowledgments We would like to thank all colleagues who have contributed to fieldwork and sampling during this study. We would especially like to thank Marius Wenzel and Sandra Telfer for collaboration with different aspects of the study, and Dave ...
Douglas, Alex +3 more
core +2 more sources
Heterozygote advantage fails to explain the high degree of polymorphism of the MHC
Immunogenetics, 2004 R. J. Boer +4 more
semanticscholar +3 more sources
BMC Medical Genetics, 2003 Background Doherty and Zinkernagel, who discovered that antigen presentation is restricted by the major histocompatibility complex (MHC, called HLA in humans), hypothesized that individuals heterozygous at particular MHC loci might be more resistant to ...
Bergstrom Carl T +2 more
doaj +1 more source