Results 51 to 60 of about 3,081,667 (237)

Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice [PDF]

, 2015
Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor ...
A Dufour, A Gutierrez-Fernandez, A Gutiérrez-Fernández, A Krüger, AM Tester, Ana Gutiérrez-Fernández, B Fingleton, B Fingleton, C López-Otín, C Soria-Valles, CM Overall, CT Guy, D Agarwal, Dylan R Edwards, E Dejonckheere, EI Deryugina, EM Bekes, EY Lin, EY Lin, G Christoffersson, G Dew, H Nozawa, J Decock, J Decock, J Decock, J Decock, J Schindelin, J Wyckoff, JE Maglione, JP Väyrynen, JP Witty, JT Korpi, JT Korpi, Julie Decock, K Almholt, L Sevenich, LH Palavalli, LJ McCawley, M Balbin, M Egeblad, M Hernández, M Lin, M Zhu, MM Gueders, N Fortelny, N Xu, P Li, P Lint Van, S Tazzyman, S Thirkettle, Sally Thirkettle, Stephen D Robinson, T Pellinen, T-Y Wu, V Knäuper, V Montel, W Wang, Wouter Hendrickx, Y Lang, Y-H Lin, Z Yang, Z-G Zhao, ZG Fridlender   +62 more
core   +3 more sources

Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats [PDF]

, 2006
Recent epidemiological studies suggest that high meat intake is associated with promotion of colon cancer linked to haem-iron intake. We previously reported that dietary haem, in the form of either haemoglobin or meat, promotes precancerous lesions in ...
Guéraud, Françoise, Jourdan, Marie-Lise, Petit, Claude, Pierre, Fabrice, Rerole, Anne-Laure, Taché, Sylviane   +5 more
core   +1 more source

Segregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection

Scientific Reports, 2020
Segregation distortion is a common phenomenon found in most genetic mapping studies and is an important resource to dissect the mechanism of action in gene loci that cause deviation.
Qiang Fu, Xianhong Meng, Sheng Luan, Baolong Chen, Jiawang Cao, Xupeng Li, Jie Kong   +6 more
doaj   +1 more source

No more time to stay ‘single’ in the detection of Anisakis pegreffii, A. simplex (s. s.) and hybridization events between them: a multi-marker nuclear genotyping approach [PDF]

, 2016
A multi-marker nuclear genotyping approach was performed on larval and adult specimens of Anisakis spp. (N = 689) collected from fish and cetaceans in allopatric and sympatric areas of the two species Anisakis pegreffii and Anisakis simplex (s.
Acerra, V., Canestrelli, D., Cipriani, P., Levsen, A., MATTIUCCI, Simonetta, Nascetti, G., Paoletti, M., Webb, S. C.   +7 more
core   +2 more sources

Genetic and environmental determinants of human TCR repertoire diversity

Immunity & Ageing, 2020
T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules. However,
Chirag Krishna, Diego Chowell, Mithat Gönen, Yuval Elhanati, Timothy A. Chan   +4 more
doaj   +1 more source

Experimental evidence for the functional importance and adaptive advantage of A-to-I RNA editing in fungi

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance RNA editing is hypothesized to facilitate adaptive evolution via flexibly diversifying the proteome temporally or spatially. However, direct experimental evidence is lacking. This study unveils the functional importance of conserved missense
Kaiyun Xin, Yang Zhang, Ligang Fan, Zhaomei Qi, Chanjing Feng, Qinhu Wang, Cong Jiang, Jin-Rong Xu, Huiquan Liu   +8 more
semanticscholar   +1 more source

RECENT INSIGHTS INTO THE POPULATION GENETICS AND DYNAMICS OF THE INHERITED DISORDERS OF HEMOGLOBIN

Mediterranean Journal of Hematology and Infectious Diseases, 2009
The inherited disorders of hemoglobin are by far the commonest monogenic diseases and there is considerable evidence that they have reached their very high frequencies due to heterozygote advantage against malaria.
David J Weatherall
doaj   +3 more sources

Balancing selection, genetic drift, and human‐mediated introgression interplay to shape MHC (functional) diversity in Mediterranean brown trout

Ecology and Evolution, 2021
The extraordinary polymorphism of major histocompatibility complex (MHC) genes is considered a paradigm of pathogen‐mediated balancing selection, although empirical evidence is still scarce.
Lorenzo Talarico, Silvio Marta, Anna Rita Rossi, Simone Crescenzo, Gerardo Petrosino, Marco Martinoli, Lorenzo Tancioni   +6 more
doaj   +1 more source

Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity

Frontiers in Immunology, 2021
HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data ...
Johannes Schetelig, Johannes Schetelig, Falk Heidenreich, Falk Heidenreich, Henning Baldauf, Sarah Trost, Bose Falk, Christian Hoßbach, Ruben Real, Axel Roers, Dirk Lindemann, Alexander Dalpke, Martin Kolditz, Katja de With, Martin Bornhäuser, Ezio E. Bonifacio, Elke Rücker-Braun, Elke Rücker-Braun, Vinzenz Lange, Jan Markert, Ralf Barth, Jan A. Hofmann, Jürgen Sauter, Stefanie N. Bernas, Alexander H. Schmidt, Alexander H. Schmidt, Alexander H. Schmidt   +26 more
doaj   +1 more source

A century of theories of balancing selection

Biological Reviews, EarlyView.
ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Ruzicka F, Zwoinska MK, Goedert D, Kokko H, Richter XL, Moodie IR, Nilén S, Olito C, Svensson EI, Czuppon P, Connallon T.   +10 more
europepmc   +2 more sources