Results 71 to 80 of about 3,081,667 (237)

Genotyping of mannose-binding lectin (MBL2) codon 54 and promoter alleles in Egyptian infants with acute respiratory tract infections

Egyptian Journal of Medical Human Genetics, 2014
Background: MBL2 gene polymorphisms affect serum concentration of mannose-binding lectin and are associated with infectious conditions. Acute respiratory tract infections are among the most prevalent infections in childhood with the highest incidence ...
Rabah M. Shawky, Sherine M. Abd El-Fattah, Tarek M. Kamal, Mohammed A. Esa, Ghada H. El Nady   +4 more
doaj   +1 more source

What explains rare and conspicuous colours in a snail? A test of time-series data against models of drift, migration or selection [PDF]

, 2016
It is intriguing that conspicuous colour morphs of a prey species may be maintained at low frequencies alongside cryptic morphs. Negative frequency-dependent selection by predators using search images ('apostatic selection') is often suggested without ...
A Bellido, A Ekendahl, A Ekendahl, A Le Rouzic, AB Bond, AC Smith, AE Scheil, AJ Cain, AJ Cain, AR Palmer, B Clarke, B Clarke, B Johannesson, BC Clarke, BC Clarke, CA McLean, CB Goodhart, D Punzalan, DG Reid, DG Reid, DJ Heath, E Rolán-Alvarez, E Svensson, GS Oxford, H Levene, H-W Chang, HA Ibarra, HBD Kettlewell, IM Sokolova, J Bots, J Gratten, JA Endler, JA Endler, K Johannesson, K Johannesson, K Johannesson, K Johannesson, K Johannesson, KA Hughes, L Excoffier, LF Delph, LM Cook, LM Cook, LM Cook, M Ozgo, M Ozgo, M Panova, M Panova, M Phifer-Rixey, M Rafajlovic, M Ravinet, M Wellenreuther, NH Barton, PE Bolton, PM Richards, PW Hedrick, PW Hedrick, PW Hedrick, R K Butlin, R Olendorf, TE Reimchen, V Castric, V Jormalainen, WD Atkinson, ZM Rosin   +64 more
core   +1 more source

Influence of Dominance and Drift on Lethal Mutations in Human Populations

Frontiers in Genetics, 2020
We consider disease-causing mutations that are lethal when homozygous. Lethality involves the very strongest form of negative selection, with the selection coefficient against the disease-carrying homozygote having its maximum value of unity.
David Waxman, Andrew D. J. Overall
doaj   +1 more source

DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study

Annals of Neurology, EarlyView.
Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito, P. Calleja, L. Alzamora, A. Ruiz‐García, A. Martínez‐Salio, M. Muñoz‐García, F. Ostos, A. García‐Culebras, A. Moraga, M.A. Moro, I. Lizasoain   +10 more
wiley   +1 more source

Under-dominance constrains the evolution of negative autoregulation in diploids [PDF]

, 2013
Regulatory networks have evolved to allow gene expression to rapidly track changes in the environment as well as to buffer perturbations and maintain cellular homeostasis in the absence of change.
Pomiankowski, A, Reuter, M, Seymour, RM, Stewart, AJ   +3 more
core  

A novel spectral method for inferring general diploid selection from time series genetic data

, 2014
The increased availability of time series genetic variation data from experimental evolution studies and ancient DNA samples has created new opportunities to identify genomic regions under selective pressure and to estimate their associated fitness ...
Bhaskar, Anand, Song, Yun S., Steinrücken, Matthias   +2 more
core   +1 more source

Methionine 129 variant of human prion protein oligomerizes more rapidly than the valine 129 variant - Implications for disease susceptibility to Creutzfeldt-Jakob disease [PDF]

, 2004
The human PrP gene (PRNP) has two common alleles that encode either methionine or valine at codon 129. This polymorphism modulates disease susceptibility and phenotype of human transmissible spongiform encyphalopathies, but the molecular mechanism by ...
Abdessamad Tahiri-Alaoui, Andrew C. Gill, Petra Disterer, William James, Prusiner, Weissmann, Will, Bruce, Hill, Prusiner, Prusiner, Collinge, Windl, Palmer, Brown, Baker, Cervenakova, Parchi, Hill, Collinge, Hauw, Goldfarb, Goldfarb, Dlouhy, Dermaut, Croes, Liemann, Riek, Alonso, Baskakov, Jackson, Baskakov, Gill, Lu, Lu, Landon, Safar, Bessen, Zahn, Riek, Nguyen, Tahiri-Alaoui, Santini, Wong, Wildegger, Matouschek, Vendruscolo, Kim, Fasman, Baskakov, Qin, Oesch, Conway, Sayer, Rhie, Schatzl, Mead   +56 more
core   +1 more source

Reviewer #3 (Public review): Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage

Joshua L Cherry
openalex   +2 more sources

Peach Kernel Oil Modulates Lipid Metabolism Disorder in ApoEa CRISPR/Cas9 Gene‐Disrupted Zebrafish

Food Frontiers, EarlyView.
In this study, we used CRISPR/Cas9 gene editing technology to establish a lipid metabolism disorder model of ApoEa mutant zebrafish. We applied peach kernel oil to this model and studied the mechanism of peach kernel oil regulating lipid disorder in combination with transcriptomics.
Lei Xia, Yuemi Mo, Yuntian Duan, Hu Liang, Yulu Li, Wanruo Wan, Minghuang Luo, Qianhua Li, Xueni Wang, Qing Chen, Zhengcai Du, Xiaotao Hou, Fan Zhang, Jiagang Deng, Erwei Hao   +14 more
wiley   +1 more source

Large-scale genomic and transcriptomic profiles of rice hybrids reveal a core mechanism underlying heterosis

Genome Biology, 2022
Background Heterosis is widely used in agriculture. However, its molecular mechanisms are still unclear in plants. Here, we develop, sequence, and record the phenotypes of 418 hybrids from crosses between two testers and 265 rice varieties from a mini ...
Jianyin Xie, Weiping Wang, Tao Yang, Quan Zhang, Zhifang Zhang, Xiaoyang Zhu, Ni Li, Linran Zhi, Xiaoqian Ma, Shuyang Zhang, Yan Liu, Xueqiang Wang, Fengmei Li, Yan Zhao, Xuewei Jia, Jieyu Zhou, Ningjia Jiang, Gangling Li, Miaosong Liu, Shijin Liu, Lin Li, An Zeng, Mengke Du, Zhanying Zhang, Jinjie Li, Ziding Zhang, Zichao Li, Hongliang Zhang   +27 more
doaj   +1 more source