Results 81 to 90 of about 3,081,667 (237)

Discovery of the Principal Cystic Fibrosis Mutation (F508del) in Ancient DNA from Iron Age Europeans [PDF]

, 2007
The most common, life-threatening autosomal recessive disease of Europeans and Euro-Americans, cystic fibrosis (CF), occurs predominately in patients with the F508del mutation.1 Although F508del is currently detectable as a single allele in 1/30-1/40 ...
Cedric Le Marechal, Claude Ferec, Malika Siker, Maria Teschler-Nicola, Philip Farrell   +4 more
core   +1 more source

Speciation with gene flow

PLANTS, PEOPLE, PLANET, EarlyView.
Biodiversity is threatened by human activities, with extinction debt accumulating rapidly. Many of these activities change the connectivity of populations, fragmenting existing population systems or bringing previously isolated populations or species into contact.
Zhiqin Long, Xu Zhang, Yue Yu, Gregory L. Owens, Diana J. Rennison, Clarisse Palma‐Silva, Daniel Ortiz‐Barrientos, Loren H. Rieseberg   +7 more
wiley   +1 more source

Does MHC heterozygosity influence microbiota form and function?

PLoS ONE, 2019
MHC molecules are essential for the adaptive immune response, and they are the most polymorphic genetic loci in vertebrates. Extreme genetic variation at these loci is paradoxical given their central importance to host health.
M A Wadud Khan, W Zac Stephens, Ahmed Dawood Mohammed, June Louise Round, Jason Lee Kubinak   +4 more
doaj   +1 more source

Diverse MHC IIB allele repertoire increases parasite resistance and body condition in the Long-tailed giant rat (Leopoldamys sabanus)

BMC Evolutionary Biology, 2009
Background Genes of the major histocompatibility complex (MHC) code for key functions in the adaptive immune response of vertebrates and most of them show exceptionally high polymorphism.
Wells Konstans, Lenz Tobias L, Pfeiffer Martin, Sommer Simone   +3 more
doaj   +1 more source

Under-dominance constrains the evolution of negative autoregulation in diploids [PDF]

, 2012
Regulatory networks have evolved to allow gene expression to rapidly track changes in the environment as well as to buffer perturbations and maintain cellular homeostasis in the absence of change.
Pomiankowski, Andrew, Reuter, Max, Seymour, Robert M., Stewart, Alexander J.   +3 more
core   +4 more sources

Comparative evaluation of noninvasive DNA sampling and line transect surveys for spring density estimation of black grouse and capercaillie

Wildlife Biology, EarlyView.
Reliable abundance estimates provide essential information in ecology, conservation and management of many wild grouse populations. In this 3‐year study, we comparatively evaluate the suitability of traditional line transect distance sampling of flushed birds versus a spatial capture–recapture survey with noninvasive DNA samples for individual ...
Henrik Brøseth, Oddmund Kleven, Kjetil Bevanger   +2 more
wiley   +1 more source

Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle.

PLoS Genetics, 2009
We herein describe the positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the recessive Crooked Tail Syndrome in cattle.
Corinne Fasquelle, Arnaud Sartelet, Wanbo Li, Marc Dive, Nico Tamma, Charles Michaux, Tom Druet, Ivo J Huijbers, Clare M Isacke, Wouter Coppieters, Michel Georges, Carole Charlier   +11 more
doaj   +1 more source

Trans-species polymorphism at antimicrobial innate immunity cathelicidin genes of Atlantic cod and related species [PDF]

PeerJ, 2015
Natural selection, the most important force in evolution, comes in three forms. Negative purifying selection removes deleterious variation and maintains adaptations.
Katrín Halldórsdóttir, Einar Árnason
doaj   +2 more sources

Integrating fecal DNA and telemetry to estimate wildlife densities in anthropogenic landscapes

Wildlife Society Bulletin, EarlyView.
Density estimation is central to wildlife management efforts but can be challenging in anthropogenic landscapes due to small parcel sizes, access restrictions, and limited green space. We evaluated (a) the use of a plot‐based spatial capture‐recapture sampling design to estimate deer density in developed landscapes and (b) if integrating telemetry data
Ashley Lynn, Mikiah McGinn, Nathan J. Hostetter, Heather Evans, Christopher E. Moorman, Nils Peterson, John Kilgo, Elizabeth M. Kierepka   +7 more
wiley   +1 more source

Genetic and phenotypic variation in wood tiger moths from the Caucasus: insights into male warning color variation

Insect Science, EarlyView.
Coloration serves several fitness‐related functions, including thermoregulation, immunity, social signaling, sexual selection, and predator avoidance. Consequently, color polymorphism can have a significant impact on a species’ interactions with its environment, including its relationships with predators, prey, and potential mates. The wood tiger moth (
Juan A. Galarza, Ossi Nokelainen, Melanie N. Brien, Cristina Ottocento, Bibiana Rojas, Janne K. Valkonen, Tamar Chunashvili, Tõnis Tasane, Chris D. Jiggins, Johanna Mappes   +9 more
wiley   +1 more source