Results 51 to 60 of about 473,993 (259)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Marketing in Heterozygous Advantage

, 2008
bioethics, marketing, heterozygous advantage,
Gregory Todd Jones, Reidar Hagtvedt, Hagtvedt, Reidar, Jones, Gregory Todd, Gregory Jones   +4 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Serotonin Transporter Genotype Modulates the Gut Microbiota Composition in Young Rats, an Effect Augmented by Early Life Stress

Frontiers in Cellular Neuroscience, 2017
The neurotransmitter serotonin (5-HT) plays a vital regulatory role in both the brain and gut. 5-HT is crucial for regulating mood in the brain as well as gastrointestinal motility and secretion peripherally.
Sahar El Aidy, Anouschka S. Ramsteijn, Francisco Dini-Andreote, Roel van Eijk, Danielle J. Houwing, Joana F. Salles, Jocelien D. A. Olivier   +6 more
doaj   +1 more source

Heterozygous variations, including heterozygous SNPs and hemizygous insertions/deletions/inversions, detected during assembly of diploid genome.

, 2016
Heterozygous variations, including heterozygous SNPs and hemizygous insertions/deletions/inversions, detected during assembly of diploid genome.
Choun-Sea Lin (173375), Ming-Tsai Chan (3353498), Sheng-Yu Chuang (3353501), Jian-Wei Chen (452345), Yao-Ting Huang (2436382), Chuan-Kang Ting (3353495)   +5 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Distribution of genotypes (compound heterozygous, heterozygous or normal) in patients with and without histopatological data.

, 2014
Note: [−] means no CF mutation detected on single chromosome.Distribution of genotypes (compound heterozygous, heterozygous or normal) in patients with and without histopatological data.
Marija Mircevska (658227), Dijana Plaseska-Karanfilska (125134), Svetlana Madjunkova (658226), Vanja Filipovski (658229), Toso Plaseski (658228), Predrag Noveski (658225)   +5 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Reduction of selection pressure of herbicides - options and limits for blackgrass management by using clethodim in oilseed rape in the presence of the Leu1781 haplotype

Julius-Kühn-Archiv, 2014
In field experiments the control of blackgrass (Alopecurus myosuroides, Huds.) in oilseed rape using clethodim (Select EC 240) and cycloxydim (Focus Ultra) with and without subsequent treatments with propyzamide (Kerb FLO) was tested at 6 locations in ...
Wagner, Jean, Heisrath, Jens, Juister, Jan, Ommen, Tjard, Günnigmann, Albert   +4 more
doaj   +1 more source