Results 101 to 110 of about 38,995 (115)

Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027

Journal of Antibiotics, 2010
Yihua Chen, Min Yin, Geoff P Horsman
exaly  

The novel microtubule-interfering agent TZT-1027 enhances the anticancer effect of radiation in vitro and in vivo

British Journal of Cancer, 2007
T Iwasa, Taroh Satoh, Okamoto I
exaly  

Phase I and pharmacokinetic study of TZT-1027, a novel synthetic dolastatin 10 derivative, administered as a 1-hour intravenous infusion every 3 weeks in patients with advanced refractory cancer

Annals of Oncology, 2004
P Schöffski
exaly  

Characterization of the Interaction of TZT-1027, a Potent Antitumor Agent, with Tubulin

Japanese Journal of Cancer Research, 2000
Tsugitaka Natsume, Motohiro Kobayashi, T Natsume   +2 more
exaly  

TZT-1027, an Antimicrotubule Agent, Attacks Tumor Vasculature and Induces Tumor Cell Death

Japanese Journal of Cancer Research, 2000
Tsugitaka Natsume, Motohiro Kobayashi, Motohiko Otani   +2 more
exaly  

Phase II study of intravenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy

Cancer, 2006
Shreyaskumar R Patel, M Wasif Saif
exaly  

Disruption ofcagA, the apoprotein gene of chromoprotein antibiotic C-1027, eliminates holo-antibiotic production, but not the cytotoxic chromophore

FEMS Microbiology Letters, 2009
Bin Hong, Wang Lifei, Li Guangwei
exaly  

Synthetic studies toward C-1027 chromophore: construction of a highly unsaturated macrocycle

Tetrahedron Letters, 2001
Masayuki Inoue
exaly  

Effects of the immunomodulator, VGX‐1027, in endotoxin‐induced uveitis in Lewis rats

British Journal of Pharmacology, 2008
Katia Mangano, Emanuela Mazzon, Salvatore Cuzzocrea   +2 more
exaly  

A phase I study of intravenous TZT-1027 administered on day 1 and day 8 of a three-weekly cycle in combination with carboplatin given on day 1 alone in patients with advanced solid tumours

Annals of Oncology, 2006
S Blagden, Gerhardt Attard, R Molife
exaly