Results 31 to 40 of about 6,414 (220)

Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD [PDF]

ACS Medicinal Chemistry Letters, 2017
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. The viral caspid protein VP1 is a well-known target for antiviral efficacy because its occupancy by suitable compounds could stabilize the virus capsid, thus ...
Peng Li, Jun Yu, Fei Hao, Haiying He, Xuyang Shi, Jiao Hu, Li Wang, Chunyan Du, Xiao Zhang, Ya Sun, Fusen Lin, Zhengxian Gu, Deming Xu, Xinsheng Chen, Liang Shen, Guoping Hu, Jian Li, Shuhui Chen, Wei Xiao, Zhenzhong Wang, Qingming Guo, Xiujuan Chang, Xuyang Tian, Tianwei Lin   +23 more
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Neuroimaging of HFMD infected by EV71

Radiology of Infectious Diseases, 2015
AbstractPediatric hand-foot-mouth disease caused by human enterovirus 71 has been prevailing in recent years in China. As it involves the central nervous system, the mortality rate remains high. The diagnosis of EV71 induced CNS damage is the key to improve the treatment of severe EV71 infection. In our study, we performed neuroimaging in patients with
Cheng, Hua, Zeng, Jinjin, Li, Hongjun, Li, Yunfang, Wang, Wei   +4 more
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A case report of severe systemic infection with neurological HFMD symptoms followed by an accidental puncture of thumb during HFMD sample collection

IDCases, 2022
A 34-year-old female clinical virology assistant was punctured with a contaminated lancet used for sampling from a suspected Hand, Foot, and Mouth disease (HFMD) patient. Five days after a puncture, the disease symptoms manifested, including high fever, ague, and stiff neck. Skin rashes suddenly appeared after day 6.
Maryam Zare, Marzieh Jamalidoust, Gholam R. Pouladfar, Ali Amanati, Maryam Shafaati, Mandana Namayandeh, Mazyar Ziyaeyan   +6 more
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Spatiotemporal cluster patterns of hand, foot, and mouth disease at the province level in mainland China, 2011-2018.

PLoS ONE, 2022
Although three monovalent EV-A71 vaccines have been launched in mainland China since 2016, hand, foot, and mouth disease (HFMD) still causes a considerable disease burden in China. Vaccines' use may change the epidemiological characters of HFMD.
Yuanzhe Wu, Tingwei Wang, Mingyi Zhao, Shumin Dong, Shiwen Wang, Jingcheng Shi   +5 more
doaj   +1 more source

Short-term effect of El Niño-Southern Oscillation on pediatric hand, foot and mouth disease in Shenzhen, China. [PDF]

PLoS ONE, 2013
Hand, foot and mouth disease (HFMD) was an emerging viral infectious disease in recent years in Shenzhen. The underlying risk factors have not yet been systematically examined.
Hualiang Lin, Hong Zou, Qinzhou Wang, Chunxiao Liu, Lingling Lang, Xuexin Hou, Zhenjun Li   +6 more
doaj   +1 more source

Modelling seasonal HFMD with the recessive infection in Shandong, China

Mathematical Biosciences and Engineering, 2013
Hand, foot and mouth disease (HFMD) is one of the major public-health problems in China. Based on the HFMD data of the Department of Health of Shandong Province, we propose a dynamic model with periodic transmission rates to investigate the seasonal HFMD.
Zhao, Jinqing, Hou, Qiang, Liu, Maoxing, Ma, Yangjun   +3 more
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Time series analysis of hand-foot-mouth disease hospitalization in Zhengzhou: establishment of forecasting models using climate variables as predictors. [PDF]

PLoS ONE, 2014
BACKGROUND: Large-scale outbreaks of hand-foot-mouth disease (HFMD) have occurred frequently and caused neurological sequelae in mainland China since 2008.
Huifen Feng, Guangcai Duan, Rongguang Zhang, Weidong Zhang   +3 more
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Time Series Analysis and Forecasting of the Hand-Foot-Mouth Disease Morbidity in China Using An Advanced Exponential Smoothing State Space TBATS Model

Infection and Drug Resistance, 2021
Chongchong Yu,1,* Chunjie Xu,2,* Yuhong Li,3 Sanqiao Yao,1 Yichun Bai,1 Jizhen Li,1 Lei Wang,4 Weidong Wu,1 Yongbin Wang1 1Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang, Henan ...
Yu C, Xu C, Li Y, Yao S, Bai Y, Li J, Wang L, Wu W, Wang Y   +8 more
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Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore

Emerging Infectious Diseases, 2003
Singapore experienced a large epidemic of hand, foot and mouth disease (HFMD) in 2000. After reviewing HFMD notifications from doctors and child-care centers, we found that the incidence of HFMD rose in September and declined at the end of October ...
Kwai Peng Chan, Kee Tai Goh, Chia Yin Chong, Eng Swee Teo, Gilbert Lau, Ai Ee Ling   +5 more
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HFMD- A Fuzzy Game Theory Model

International Journal of Biomedical and Advance Research, 2021
In this project, we developed a fuzzy game theory model for Hand Foot Mouth disease (HFMD), a transmissible disease affecting many populations around the world. HFMD is fomented from the genus enteroviruses.   Although there are several viruses, coxsackie virus enteroviruses 71 (EV71) and A16 [5] are most probable to produce this disease ...
Ross, H., Roy, Ajanta, Smith, K.
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