Aims Guidelines for management of patients with heart failure with mid‐range ejection fraction [HFmrEF; left ventricular EF (LVEF) 41–49%] do not exist. Disagreement exists whether HFmrEF should be considered a distinct group. The aim of this study is to
Nasrien E. Ibrahim +7 more
doaj +1 more source
A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure [PDF]
Aims Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy).
Anker, Stefan D. +18 more
core +5 more sources
The purpose of the study was to establish clinical features of permanent atrial fibrillation (AF) in patients with heart failure mid-range ejection fraction (HFmrEF) and to develop a mathematical model for predicting arrhythmia development.
O. O. Khaniukov +3 more
doaj +1 more source
Kalzium-abhängige zelluläre Mechanismen ventrikulärer und atrialer Dysfunktion bei Herzinsuffizienz [PDF]
In der vorliegenden Arbeit werden Mechanismen und therapeutische Ziele der ventrikulären und atrialen Dysfunktion sowie deren Relevanz im Kontext einer systolischen oder diastolischen Herzinsuffizienz vorgestellt. Die zentralen Hypothesen sind: 1.
Hohendanner, Felix
core +1 more source
Aims Limited data are available on the outcomes of cryoballoon ablation (CBA)‐based pulmonary vein isolation (PVI) for atrial fibrillation (AF) in patients with heart failure (HF) with preserved ejection fraction (HFpEF) and mildly reduced ejection ...
Chaofeng Chen +10 more
doaj +1 more source
The Role of Cathepsin D in the Pathophysiology of Heart Failure and its Potentially Beneficial Properties:a translational approach [PDF]
Aims: Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown.
Adriaan A. Voors +16 more
core +3 more sources
Machine learning models in heart failure with mildly reduced ejection fraction patients
ObjectiveHeart failure with mildly reduced ejection fraction (HFmrEF) has been recently recognized as a unique phenotype of heart failure (HF) in current practical guideline. However, risk stratification models for mortality and HF re-hospitalization are
Hengli Zhao +22 more
doaj +1 more source
Effect of β-blockers on 1-year survival and hospitalizations in patients with heart failure and atrial fibrillation: results from ESC-HF pilot and ESC-HF long-term registry [PDF]
[Abstract] Introduction The positive effect of β-blocker therapy in patients with heart failure (HF) and atrial fibrillation (AF) has been questioned. Objectives We aimed to assess the effect of β-blockers and heart rate (HR) control on 1-year outcomes ...
Balsam, Pawel +11 more
core +2 more sources
Impact of left ventricular ejection fraction on the effect of renin-angiotensin system blockers after an episode of acute heart failure: From the KCHF Registry [PDF]
Objective: This observational study aimed to examine the prognostic association of angiotensin-converting enzyme inhibitors (ACE-I)/angiotensin receptor blockers (ARB) in different left ventricular ejection fraction (LVEF) categories.
Inuzuka, Yasutaka +15 more
core +1 more source
A heart failure phenotype stratified model for predicting 1-year mortality in patients admitted with acute heart failure:results from an individual participant data meta-analysis of four prospective European cohorts [PDF]
Background Prognostic models developed in general cohorts with a mixture of heart failure (HF) phenotypes, though more widely applicable, are also likely to yield larger prediction errors in settings where the HF phenotypes have substantially different ...
Akkerhuis, K. Martijn +8 more
core +6 more sources

