Results 101 to 110 of about 20,268 (224)

Nephrological perspectives on the underutilization of SGLT2is in heart failure and chronic kidney disease

ESC Heart Failure, Volume 12, Issue 2, Page 1490-1491, April 2025.
Özant Helvacı, Ömer Faruk Akçay, Emre Yaşar, Ülver Derici, Galip Güz   +4 more
wiley   +1 more source

Healthcare Resource Utilisation and Cost of Obesity and Related Complications in the United States: A Systematic Literature Review

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Obesity is an increasingly prevalent, chronic, heterogeneous disease, associated with a variety of obesity‐related complications (ORCs). This systematic literature review assessed US healthcare resource utilisation (HCRU) and costs (direct and indirect) for people living with obesity (PwO) or overweight and ORCs.
Jaime P. Almandoz, Jamy D. Ard, Chellse Gazda, Shenelle Edwards‐Hampton   +3 more
wiley   +1 more source

Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis

Cardiovascular Diabetology
Background Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent clinical syndrome with high morbidity and mortality. Although HFpEF frequently coexists with cardiometabolic diseases, the causal mechanisms and potential ...
Mingzhi Lin, Jiuqi Guo, Hongqian Tao, Zhilin Gu, Wenyi Tang, Fuliang Zhou, Yanling Jiang, Ruyi Zhang, Dalin Jia, Yingxian Sun, Pengyu Jia   +10 more
doaj   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Nocturnal Hypoxemic Burden Predicts Mortality in Patients Awaiting Heart Transplantation

Journal of Sleep Research, EarlyView.
Trial design and results on hypoxemic burden in the context of heart transplantation. ABSTRACT Risk stratification for patients with end‐stage heart failure (HF) awaiting heart transplantation (HTX) is crucial. Sleep‐disordered breathing (SDB) is a prevalent comorbidity, yet the impact of its resultant hypoxemic burden remains unclear in this ...
Max Potratz, Tatevik Manukyan, René Schramm, Angelika Costard‐Jäckle, Uwe Fuchs, Michiel Morshuis, Sabina P. W. Guenther, Sebastian V. Rojas, Volker Rudolph, Jan F. Gummert, Henrik Fox   +10 more
wiley   +1 more source

Real‐World Treatment of Patients With Sinus Node Dysfunction and Heart Failure With Preserved Ejection Fraction

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Permanent pacemaker (PPM) implantation is recommended in patients with sinus node dysfunction (SND). In patients with coexisting heart failure with preserved ejection fraction (HFpEF), clinicians may be hesitant to treat SND due to concerns about exacerbating heart failure.
Nicole Habel, Sarah Rosemas, Lucas Higuera, Patrick Zimmerman, Markus Meyer   +4 more
wiley   +1 more source

Linking dynamic cerebral autoregulation and inhibitory executive function: Role of modifiable behaviours

Experimental Physiology, EarlyView.
Abstract Dynamic cerebral autoregulation (dCA) stabilises cerebral blood flow (CBF) against rapid fluctuations in perfusion pressure and may serve as a key physiological mediator of cognitive function. Inhibitory executive function, a core domain essential for goal‐directed behaviour, is influenced by modifiable lifestyle factors such as physical ...
Hayato Tsukamoto, Damian M. Bailey
wiley   +1 more source

Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy

Experimental Physiology, EarlyView.
Abstract Attenuation of sympathetic vasoconstriction during exercise (functional sympatholysis) contributes to skeletal muscle oxygen delivery–utilization matching. However, the extent to which muscle contractions impact noradrenergic regulation of interstitial oxygen pressures (PO2is${P_{{{\mathrm{O}}_2}}}_{{\mathrm{is}}}$; the driving force for blood–
Edward T. N. Calvo, Jacob M. Pontorno, Benjamin Zeidler, Taciane M. M. Pejon, Michael D. Belbis, Scott K. Ferguson, Craig J. Goergen, Timothy P. Gavin, Bruno T. Roseguini, Igor A. Fernandes, Daniel M. Hirai   +10 more
wiley   +1 more source

Strain‐based characterization of atrioventricular and left atrial remodelling in rat models of heart failure with preserved ejection fraction

Experimental Physiology, EarlyView.
Abstract Current experimental models of heart failure with preserved ejection fraction (HFpEF) lack standardized approaches for evaluating left atrial (LA) remodelling and atrioventricular (AV) coupling, leaving a critical gap in mechanistic understanding and phenotypic characterization. This study aimed to explore LA function and AV coupling status in
Qingfeng Zhang, Wenhua Li, Hongmei Zhang, Yi Wang, Lixue Yin   +4 more
wiley   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source