Results 341 to 350 of about 43,089 (386)

Lung‐Derived Small Extracellular Vesicles Containing miR‐15a‐5p/miR‐96‐5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7

Small, EarlyView.
Small extracellular vesicles (sEVs) are critical regulators of inter‐tissue communication in cardiovascular diseases. In this study, it is found that lung‐derived sEVs enhance cardiac fibroblasts activation and aggravates myocardial fibrosis progression in hypertrophic cardiomyopathy (HCM). sEVmiR‐15a‐5p and sEVmiR‐96‐5p exert this effect via targeting
Minwen Long, Jinpeng Sun, Dongli Zhou, Can Chen, Jiangcheng Shu, Xiaobo Mao, Kunwu Yu, Minglu Liang, Long Chen, Yumei Wang, Min Cheng   +10 more
wiley   +1 more source

Heterogeneity in Heart Failure with Preserved Ejection Fraction: A Systematic Review of Phenotypic Classifications and Clinical Implications. [PDF]

J Clin Med
Epelde F.
europepmc   +1 more source

The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression

Aging Cell, EarlyView.
A multi‐omics analysis was performed to uncover the molecular landscape of human cardiac ageing. We report several insights for the first time: a decrease in proteins composing the structural machinery of the heart; a likely compensatory increase in energetic flux and redox reductive capacity; and an increase in lysosomal activity.
Cassandra Malecki, Giovanni Guglielmi, Benjamin Hunter, Dylan Harney, Yen Chin Koay, Anthony. S. Don, Oscar Han, Jasmine Khor, Lisa Nguyen, Michael Pan, Peter Gawthrop, Nathan Isles, Joshua Chung, Robert. D. Hume, Matthew Taper, XiaoSuo Wang, Mark Larance, Fabian Spill, Vijay Rajagopal, John F. O’Sullivan, Sean Lal   +20 more
wiley   +1 more source

Association between antecedent myocardial infarction and heart failure with preserved versus reduced ejection fraction

European Journal of Heart Failure, EarlyView.
Mohammad A. Almesned, Bart J. van Essen, Johanna. E. Emmens, Jasper Tromp, Marcelle D. Smit, Christiane A. Geluk, Ron T. Gansevoort, Stephan. J.L. Bakker, Kevin Damman, Rudolf A. de Boer, Dirk J. van Veldhuisen, Adriaan A. Voors, Erik Lipsic   +12 more
wiley   +1 more source

Skeletal Muscle Alterations in Different Phenotypes of Heart Failure with Preserved Ejection Fraction. [PDF]

Int J Mol Sci
Vahle B, Klädtke R, Schauer A, Bowen TS, Wisløff U, Linke A, Adams V.   +6 more
europepmc   +1 more source

TRPM7 Kinase and Mitochondrial Dysfunction in Diabetic Heart Failure With Preserved Ejection Fraction: A Molecular Entry Point to a Complex Disease. [PDF]

JACC Basic Transl Sci
Koitabashi N.
europepmc   +1 more source

Intravenous iron in heart failure: still no prognostic impact, but questions remain. [PDF]

Int J Cardiol Heart Vasc
El-Battrawy I, Hamdani N, Abumayyaleh M, Akin I.   +3 more
europepmc   +1 more source

Association of serum potassium time in target range with cardiovascular outcomes in patients with HFpEF. [PDF]

Open Heart
Xu W, Xiao Z, Tang Y, Li Y, Chen X, He F, Huang H, Li C, Liu Y, Zhou J, Wang Y, Bin J, Chen Y.   +12 more
europepmc   +1 more source

Targeted Overexpression of Mitochondrial ALDH2 in Coronary Endothelial Cells Mitigates HFpEF in a Diabetic Mouse Model. [PDF]

Biomolecules
Pan G, Roy B, Yeboah EO, Lanigan T, Hilgarth R, Thandavarayan RA, Petriello MC, Giri S, Palaniyandi SS.   +8 more
europepmc   +1 more source