Results 41 to 50 of about 32,390 (296)

Impact of severe secondary tricuspid regurgitation on rest and exercise hemodynamics of patients with heart failure and a preserved left ventricular ejection fraction

Frontiers in Cardiovascular Medicine, 2023
BackgroundBoth secondary tricuspid regurgitation (STR) and heart failure with preserved ejection fraction (HFpEF) are relevant public health problems in the elderly population, presenting with potential overlaps and sharing similar risk factors. However,
Claudia Baratto, Sergio Caravita, Sergio Caravita, Giorgia Corbetta, Giorgia Corbetta, Davide Soranna, Antonella Zambon, Antonella Zambon, Céline Dewachter, Mara Gavazzoni, Francesca Heilbron, Michele Tomaselli, Noela Radu, Francesco Paolo Perelli, Francesco Paolo Perelli, Giovanni Battista Perego, Jean-Luc Vachiéry, Gianfranco Parati, Gianfranco Parati, Luigi P. Badano, Luigi P. Badano, Denisa Muraru, Denisa Muraru   +22 more
doaj   +1 more source

Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Patients with heart failure and preserved ejection fraction (HFpEF) are at high risk of mortality, hospitalizations, and reduced functional capacity and quality of life.
P. Armstrong, C. Lam, K. Anstrom, J. Ezekowitz, Adrian F. Hernandez, C. O'connor, B. Pieske, P. Ponikowski, Sanjiv J. Shah, S. Solomon, A. Voors, Lilin She, Vanja Vlajnic, F. Carvalho, L. Bamber, R. Blaustein, L. Roessig, J. Butler   +17 more
semanticscholar   +1 more source

PINK1 Phosphorylates Drp1S616 to Improve Mitochondrial Fission and Inhibit the Progression of Hypertension-Induced HFpEF

International Journal of Molecular Sciences, 2022
(1) Background: Heart failure with preserved ejection fraction (HFpEF) is a major subtype of HF with no effective treatments. Mitochondrial dysfunctions relevant to the imbalance of fusion and fission occur in HFpEF.
J. Shou, Yunlong Huo
semanticscholar   +1 more source

Ferric carboxymaltose and exercise capacity in heart failure with preserved ejection fraction and iron deficiency: the FAIR-HFpEF trial

European Heart Journal
Background and Aims Evidence is lacking that correcting iron deficiency (ID) has clinically important benefits for patients with heart failure with preserved ejection fraction (HFpEF).
Stephan von Haehling, W. Doehner, R. Evertz, T. Garfias-Veitl, Carlotta Derad, Monika Diek, Mahir Karakas, Ralf Birkemeyer, Gerasimos Fillippatos, M. Lainščak, J. Butler, P. Ponikowski, Michael Böhm, T. Friede, S. Anker   +14 more
semanticscholar   +1 more source

Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)

Frontiers in Cardiovascular Medicine, 2022
Although the prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, evidence-based therapies for HFpEF remain limited, likely due to an incomplete understanding of this disease.
M. Valero-Muñoz, E. Saw, Ryan M. Hekman, B. Blum, Z. Hourani, H. Granzier, A. Emili, F. Sam   +7 more
semanticscholar   +1 more source

Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis

Brazilian Journal of Medical and Biological Research
Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have symptoms and signs of HF with normal or near-normal left ventricular ejection fraction (LVEF ≥50%).
Chao Ma, Huan Luo, Lei Fan, Xiaoyan Liu, Chengshan Gao   +4 more
doaj   +1 more source

Resistant hypertension in elderly: a clinical manifestation of heart failure with preserved ejection fraction? retrospective single-center analysis

Clinical and Experimental Hypertension, 2019
Background: Resistant hypertension (RHT) is defined as high blood pressure despite three antihypertensive medications one being a diuretic. RHT is a common clinical problem and as a subgroup has not been studied widely. The present study has investigated
Ebru Ipek Turkoglu, Emine Cigdem Kircicegi Cıcekdag   +1 more
doaj   +1 more source

Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing

Biomedicines, 2023
Heart failure with preserved ejection fraction (HFpEF) is emerging as a widespread disease with global socioeconomic impact. Patients with HFpEF show a dramatically increased morbidity and mortality, and, unfortunately, specific treatment options are ...
Michael Wester, Michael Arzt, Frederick Sinha, Lars Siegfried Maier, Simon Lebek   +4 more
doaj   +1 more source

Protein biomarkers of cardiac remodeling and inflammation associated with HFpEF and incident events

Scientific Reports, 2022
There is increasing evidence that HFpEF is a heterogeneous clinical entity and distinct molecular pathways may contribute to pathophysiology. Leveraging unbiased proteomics to identify novel biomarkers, this study seeks to understand the underlying ...
J. Regan, L. Truby, Usman A. Tahir, Daniel H. Katz, M. Nguyen, L. Kwee, Shuliang Deng, James G. Wilson, R. Mentz, W. Kraus, Adrian F. Hernandez, R. Gerszten, E. Peterson, R. Holman, Svati H. Shah   +14 more
semanticscholar   +1 more source

Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation

Advanced Science, EarlyView.
Metabolomics analyses reveal that trigonelline is markedly reduced in HFpEF hearts. Trigonelline supplementation alleviates metabolic disorders and improves cardiac function in HFpEF mice via gut microbiota‐mediated AMPK activation. Abstract Heart failure with preserved ejection fraction (HFpEF) is a prevalent end‐manifestation of cardiovascular ...
Zhe Cheng, Xiaowen Wang, Jiang Yu, Xiaorong Li, Qing Tang, Can Qu, Ding Yang, Yuanjing Li, Yong Xia, Yongzheng Guo   +9 more
wiley   +1 more source