Results 231 to 237 of about 11,687 (237)

Lack of interchangeability of Hfq-like proteins

Biochimie, 2012
Hfq is an RNA-binding protein that participates in the regulatory activity of small non-coding RNAs (sRNAs) in many species of bacteria. Hfq protein was first crystallized from Staphylococcus aureus and this crystal structure constitutes a hallmark for bacterial Sm-like proteins. Paradoxically, however, the functional relevance/role of S.
Nara Figueroa-Bossi, Lionello Bossi, Qi Yang, Tatiana Rochat, Philippe Bouloc   +4 more
openaire   +3 more sources

Bacterial Small Regulatory RNAs and Hfq Protein

Biochemistry (Moscow), 2015
Small regulatory RNA (sRNA) is a unique noncoding RNA involved in regulation of gene expression in both eukaryotic and bacterial cells. This short review discusses examples of positive and negative translation regulation by sRNAs in bacteria and participation of Hfq in these processes. The importance of structure investigation of nucleotide-protein and
Victoriia Murina, Alexey D. Nikulin
openaire   +3 more sources

RNA Chaperones Step Out of Hfq’s Shadow

Trends in Microbiology, 2017
The stability and function of regulatory small RNAs (sRNAs) often require a specialized RNA-binding protein called an RNA chaperone. Recent findings show that proteins containing a ProQ/FinO domain constitute a new class of RNA chaperones that could play key roles in post-transcriptional gene regulation throughout bacterial species.
Attaiech, Laetitia, Glover, J. N. Mark, Charpentier, Xavier   +2 more
openaire   +4 more sources

Functional effects of variants of the RNA chaperone Hfq

Biochemical and Biophysical Research Communications, 2004
The ring-shaped RNA chaperone Hfq has recently received much attention owing to its multiple roles in RNA metabolism. In this study we have performed a mutational analysis of the Escherichia coli hfq gene, and have studied the effects of amino acid substitutions at several positions in the Hfq protein as well as of C-terminal truncations on its role in
Isabella Moll, Taras Afonyushkin, Johanna Napetschnig, Karin Ecker, Vladimir R. Kaberdin, Branislav Večerek, Udo Bläsi, Elisabeth Sonnleitner   +7 more
openaire   +3 more sources

Ironing out Hfq regulation

Nature Reviews Microbiology, 2012
The stringent response regulator RelA promotes multimerization of Hfq and increases its affinity for target small RNAs.
openaire   +3 more sources

Hfq-associated Regulatory Small RNAs

2012
Regulatory RNAs in bacteria represent a diverse group of molecules that act through a variety of intricate mechanisms to modulate a broad range of physiological responses. Some regulatory RNAs act to modulate protein function, often by acting as molecular mimics of other nucleic acids that are regulatory targets of the protein and thus capturing the ...
Colin P. Corcoran, Jörg Vogel, Kai Papenfort   +2 more
openaire   +2 more sources

IDENTIFICATION AND CHARACTERIZATION OF HFQ AND HFQ-REGULATED SMALL RNAS IN ERWINIA AMYLOVORA

Acta Horticulturae, 2014
Q. Zeng, George W. Sundin
openaire   +2 more sources