Results 21 to 30 of about 6,414 (170)

The oxidative debt of fasting : evidence for short to medium-term costs of advanced fasting in adult king penguins [PDF]

, 2016
This research was funded by the French Polar Institute (IPEV–Research Program 119) and the French National Centre for Scientific Research (CNRS-INEE). We are especially grateful to Dominic L.
Bize, Pierre, Criscuolo, François, Lefol, Emilie, Robin, Jean-Patrice, Saadaoui, Hédi, Schull, Quentin, Stier, Antoine, Viblanc, Vincent A.   +7 more
core   +3 more sources

Dynamics of viscoelastic pipe flow in the maximum drag reduction limit [PDF]

, 2018
Polymer additives can substantially reduce the drag of turbulent flows and the upper limit, the so called "maximum drag reduction" (MDR) asymptote is universal, i.e. independent of the type of polymer and solvent used.
Choueiri, George H., Hof, Bjoern, Lopez, Jose M.   +2 more
core   +2 more sources

Full-depth Coadds of the WISE and First-year NEOWISE-Reactivation Images

, 2016
The Near Earth Object Wide-field Infrared Survey Explorer (NEOWISE) Reactivation mission released data from its first full year of observations in 2015.
Lang, Dustin, Meisner, Aaron M., Schlegel, David J.   +2 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Fitness implications of seasonal climate variation in Columbian ground squirrels [PDF]

, 2016
The influence of climate change on the fitness of wild populations is often studied in the context of the spring onset of the reproductive season. This focus is relevant for climate influences on reproductive success, but neglects other fitness- relevant
Dobson, F. Stephen, Lane, Jeffrey E., Low, Matthew, Murie, Jan O.   +3 more
core   +1 more source

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

Biological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon, Neil J. Gostling, Ian G. Reddin, Bram G. Sengers, Pascale Chavatte‐Palmer, Rohan M. Lewis   +5 more
wiley   +1 more source

Realising Team-Working in the Field: An Agent-based Approach [PDF]

, 2007
Multi-agent systems technology is applied to enable co-operation between mobile workers in the field, minimising user intervention and increasing reachability.
Lee, H, Mihailescu, P, Shepherdson, J
core  

The Individual and Combined Effects of Warming and Atrazine on Lithobates pipiens Phenotypes: Implications for Frog Declines

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Amphibians are the most threatened vertebrate class globally. Climate change, agrochemicals, and/or pathogens and parasites are implicated in contributing to amphibian declines, either singly or in combination. We investigated individual and combined effects of elevated temperatures and atrazine (2.0 μg/L) on Lithobates [formerly Rana] pipiens
Melody J. Gavel, Mark R. Forbes, Derek D. N. Smith, Julia Darabaner, Yol Monica Reyes, Zintis Stasko, David J. Carpenter, Stacey A. Robinson   +7 more
wiley   +1 more source