MANET 3.0: Hierarchy and modularity in evolving metabolic networks.
PLoS ONE, 2019 Enzyme recruitment is a fundamental evolutionary driver of modern metabolism. We see evidence of recruitment at work in the metabolic Molecular Ancestry Networks (MANET) database, an online resource that integrates data from KEGG, SCOP and structural ...
Fizza Mughal, Gustavo Caetano-Anollés
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Drawing Valid Inferences From The Nested Structure Of Engineering Education Data: Application Of A Hierarchical Linear Model To The Succeed Longitudinal Database [PDF]
, 2020 Miguel A. Padilla +3 more
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Advanced Science, EarlyView.Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai +15 more
wiley +1 more source
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Advanced Science, EarlyView.Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun +7 more
wiley +1 more source
Modeling and analysis for an enhanced three-tier dynamic location management in 3G
Tongxin xuebao, 2006 Based on 3G cellular networks where the home location registers, gateway location registers and visitor loca- tion registers formed a three-tier hierarchical mobility database structure, an enhanced movement-based location management scheme was presented.
ZHANG Hao +3 more
doaj +2 more sources
Hierarchical Fusion Transformer for Multimodal Ground-Based Cloud Type Classification
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingExisting methods for multimodal ground-based cloud type classification are dominated by convolutional neural networks, and it fails to capture long-range dependencies.
Shuang Liu +4 more
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Beyond Sectionality and Into Sizeness, or How Course Size Effects Grades: An Exploration of the Multiple‐Institution Database for Investigating Engineering Longitudinal Development Through Hierarchical Linear Models [PDF]
, 2015 George Ricco
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Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development
Advanced Science, EarlyView.The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu +12 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui +14 more
wiley +1 more source