Results 41 to 50 of about 974,133 (275)

Geometry of River Networks II: Distributions of Component Size and Number [PDF]

, 2000
The structure of a river network may be seen as a discrete set of nested sub-networks built out of individual stream segments. These network components are assigned an integral stream order via a hierarchical and discrete ordering method.
A. D. Abrahams, A. E. Scheidegger, A. Maritan, A. Maritan, A. N. Strahler, A. Rinaldo, A. Rinaldo, B. B. Mandelbrot, C. M. Bender, C. P. Stark, D. G. Tarboton, D. G. Tarboton, D. L. Turcotte, Daniel H. Rothman, E. Tokunaga, E. Tokunaga, E. Tokunaga, G. S. Kassab, G. S. Kassab, G. S. Kassab, H. de Vries, I. Gradshteyn, I. Rodríguez-Iturbe, J. T. Hack, J. W. Kirchner, L. B. Leopold, M. Zamir, M. Zamir, P. La Barbera, P. S. Dodds, P. S. Dodds, P. S. Dodds, P. S. Dodds, Peter Sheridan Dodds, R. E. Horton, S. A. Schumm, S. Aharinejad, S. D. Peckham, S. Peckham, S. S. Manna, T. Sun, W. B. Langbein, W. Feller   +42 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The supervised hierarchical Dirichlet process [PDF]

, 2014
We propose the supervised hierarchical Dirichlet process (sHDP), a nonparametric generative model for the joint distribution of a group of observations and a response variable directly associated with that whole group.
Dai, Andrew M., Storkey, Amos J.
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

An experimental investigation of fairness and reciprocal behavior in a triangular principal-multiagent relationship [PDF]

, 2001
Issues of fairness in hierarchies have been mostly investigated - both theoretically and experimentally - within dyadic principle-agent relationships.
Rossi, Alessandro, Warglien, Massimo
core  

Bayesian hierarchical modeling for signaling pathway inference from single cell interventional data

, 2011
Recent technological advances have made it possible to simultaneously measure multiple protein activities at the single cell level. With such data collected under different stimulatory or inhibitory conditions, it is possible to infer the causal ...
Luo, Ruiyan, Zhao, Hongyu
core   +1 more source

Taking time to understand: articulating relationships between technologies and organizations [PDF]

, 2010
Dynamic relationships between technologies and organizations are investigated through research on digital visualization technologies and their use in the construction sector.
Whyte, Jennifer
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

CellWalker2: Multi-omic discovery using hierarchical cell type relationships

Cell Genomics
Summary: Tissues are composed of cells with a wide range of similarities to each other, yet existing methods for single-cell genomics treat cell types as discrete labels.
Zhirui Hu, Pawel F. Przytycki, Katherine S. Pollard   +2 more
doaj   +1 more source