Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning
Advanced Science, EarlyView.ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen +6 more
wiley +1 more source
Advanced Science, EarlyView.Tunable dynamics of an interface‐type memristor array enabled by dual‐ion modulation through Ag nanoclusters are demonstrated. A 32 × 32 one‐resistor (1R) array exhibits 100% yield with high temporal/spatial uniformity (<3%) and a rectification ratio of 105.
Yoonho Cho +7 more
wiley +1 more source
Contrasting predictive coding and representational accounts of perceptual organization, stimulus predictability, and attentional modulation in the visual cortical hierarchy. [PDF]
Neurosci ConsciousDomijan D.
europepmc +1 more source
Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity
Advanced Science, EarlyView.Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang +12 more
wiley +1 more source
Enhancing Crisis Preparedness in Healthcare Facilities: A Risk-Based Assessment Tool for Preventing Targeted Violent Attacks. [PDF]
Risk Manag Healthc PolicyZajíc M, Tušer I, Jánský J.
europepmc +1 more source
Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction
Advanced Science, EarlyView.We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen +3 more
wiley +1 more source
Advanced Science, EarlyView.This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley +1 more source
DAIS-MQTT: A Distributed MQTT Communication Method Based on Intelligent QoS Routing and Hierarchical Collaboration. [PDF]
Sensors (Basel)Lian M +5 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun +10 more
wiley +1 more source
Building MCP-native hierarchical AI scientist ecosystems: a perspective on scaling multi-agent scientific discovery. [PDF]
Front Artif IntellYue L, Ko CY, Chen PY, Di S, Pan S.
europepmc +1 more source