Higenamine in Plants as a Source of Unintentional Doping [PDF]
Plants, 2022 Background: Higenamine is a β2 agonist of plant origin. The compound has been included in WADA’s prohibited list since 2017. Higenamine may be detected in different plants and many food supplements of natural origin.
Kalin Ivanov, Stanislava Ivanova
exaly +8 more sources
Role of Higenamine in Heart Diseases: A Mini-Review [PDF]
Frontiers in Pharmacology, 2022 Higenamine, a natural product with multiple targets in heart diseases, is originally derived from Aconitum, which has been traditionally used in China for the treatment of heart disease, including heart failure, arrhythmia, bradycardia, cardiac ischemia ...
Jian-xia Wen, Chuan Liu, Yanling Zhao
exaly +7 more sources
Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial [PDF]
Frontiers in Psychology, 2021 The aim of this study was to determine the ergogenic effects and the safety profile of a one-component higenamine supplement in female recreational athletes. Twelve recreational female basketball players (age 29–41 years, oxygen consumption (VO2max) >
Jelena S. Rasic +11 more
doaj +7 more sources
The Antioxidant Capability of Higenamine: Insights from Theory [PDF]
Antioxidants, 2020 Density functional theory was employed to highlight the antioxidant working mechanism of higenamine in aqueous and lipid-like environments. Different reaction mechanisms were considered for the reaction of higenamine with the •OOH radical.
Isabella Romeo +2 more
exaly +7 more sources
pH Effect and Chemical Mechanisms of Antioxidant Higenamine [PDF]
Molecules, 2018 In this article, we determine the pH effect and chemical mechanism of antioxidant higenamine by using four spectrophotometric assays: (1) 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide radical (PTIO•)-scavenging assay (at pH 4.5, 6.0, and 7 ...
Xican Li, Dongfeng Chen
exaly +5 more sources
Higenamine, Anti-Doping, and Plant-Based Cuisine: A Legal Analysis of Higenamine in Sport Anti-Doping Systems [PDF]
Laws, 2022 Current anti-doping policy seeks to protect honest athletes from biochemically overeducated colleagues. However, there is a question of whether the present policy has gone too far.
Salomeja Zaksaite
doaj +3 more sources
Biphasic Tracheal Relaxation Induced by Higenamine and Nantenine From Nandina domestica THUNBERG
Journal of Pharmacological Sciences, 2011 We compared the effects of the extract from fruits of Nandina domestica THUNBERG (NDE) and its constituents, higenamine and nantenine, on contractile responses in isolated guineapig trachea.
Takuro Ueki +4 more
doaj +6 more sources
Synthesis and Detailed Examination of Spectral Properties of (S) and (R)-Higenamine 4′-O-β-d-Glucoside and HPLC Analytical Conditions to Distinguish the Diastereomers [PDF]
Molecules, 2017 Higenamine is a tetrahydroisoquinoline present in several plants that has β-adrenergic receptor agonist activity. Study of the biosynthesis of higenamine has shown the participation of norcoclaurine synthase, which controls the stereochemistry to ...
Eisuke Kato, Ryohei Iwata, Jun Kawabata
doaj +2 more sources
Metabolomics coupled with integrated approaches reveal the therapeutic effects of higenamine combined with [6]-gingerol on doxorubicin-induced chronic heart failure in rats [PDF]
Chinese Medicine, 2020 Background This study was aimed to investigate the therapeutic effects and potential mechanism of higenamine combined with [6]-gingerol (HG/[6]-GR) against doxorubicin (DOX)—induced chronic heart failure (CHF) in rats.
Jianxia Wen +8 more
doaj +2 more sources
Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model [PDF]
Natural Products and Bioprospecting, 2018 The Phytochemical investigation on MeOH extract on the bark of Aristolochia brasiliensis Mart. & Zucc (Aristolochiaceae) led to the isolation of major compound (1) as light brown grainy crystals. The compound was identified as 1-(4-hydroxybenzyl)-1,2,3,4-
Paul Erasto +6 more
doaj +2 more sources