Results 161 to 170 of about 1,066 (203)

Determination of higenamine in dietary supplements by UHPLC/MS/MS method

Journal of Pharmaceutical and Biomedical Analysis, 2017
From 1st January 2017 higenamine was added on the WADA (World Anti-doping Agency) Prohibited list under S3 group beta-2 agonists as at all times banned substance for the athletes. The main origine of higenamine (or norcoclaurine) are different plants including Nandina domestica, Aconitum carmichaelii, Asarum heterotropioides, Galium divaricatum, Annona
Nenad Dikić, Biljana Jančić-Stojanović   +1 more
exaly   +5 more sources

Clinical safety assessment of oral higenamine supplementation in healthy, young men

Human and Experimental Toxicology, 2015
Objective: Higenamine, an herbal agent also known as norcoclaurine, is thought to stimulate β-androgenic receptors and possess lipolytic activity. It is currently making its way into the dietary supplement market. To our knowledge, no studies have been conducted to determine the safety profile of oral higenamine when used alone and in conjunction with ...
R J, Bloomer, J M, Schriefer, T A, Gunnels   +2 more
exaly   +3 more sources

Bronchodilatory Effect of Higenamine as Antiallergic Asthma Treatment

Journal of Investigative Medicine, 2022
Asthma is a complex airway disease that affects more than 350 million humans worldwide. Allergic asthma symptoms are induced by Th2 immune response with the release of cytokines and allegro-inflammatory mediators that amplify the inflammatory response, airway hyper-responsiveness (AHR) and hyperproduction of mucus.
Jing Du, Entezar Mehrabi Nasab, Seyyed Shamsadin Athari, Linlin Qian   +3 more
openaire   +2 more sources

Anti-Thrombotic Effects of Higenamine

Planta Medica, 2001
The anti-platelet and anti-thrombotic effects of higenamine, a benzyltetrahydroisoquinoline alkaloid of the roots of Aconitum japonicum (Ranunculaceae), were investigated. The degree of platelet aggregation was measured with platelet rich plasma (PRP).
H S, Yun-Choi, M K, Pyo, K M, Park, K C, Chang, D H, Lee   +4 more
openaire   +2 more sources

PHARMACOKINETICS OF HIGENAMINE IN RABBITS

Biopharmaceutics & Drug Disposition, 1996
The pharmacokinetics of higenamine were investigated in rabbits by IV bolus, PO route, and IV infusion. Plasma higenamine concentration declined rapidly in a biexponential pattern, with a terminal half-life of 22 min. The AUC increased proportionally with increasing dose, whereas the percentage of unchanged higenamine excreted from urine remained ...
C F, Lo, C M, Chen
openaire   +2 more sources

Synthesis of [3H]-higenamine

Journal of Radioanalytical and Nuclear Chemistry, 2003
The synthesis of [3H]-higenamine by a four steps reaction, namely condensation, cyclization, catalytic tritiation and demethoxylation is described. The acidulated product was purified by thin layer chromatography and the final component has a high specific activity and radiochemical purity.
Dezhu Wu, Zheng Zhang, Baoling Chen, Ginfu Li   +3 more
openaire   +1 more source

Applications of Higenamine in pharmacology and medicine

Journal of Ethnopharmacology, 2017
Aconitum has been used as local and traditional medicines in many asian regions for the treatment of various diseases such as collapse, syncope, painful joints, oedema, bronchial asthma et al. Higenamine, a plant-based alkaloid, was initially isolated from Aconitum and identified as the active cardiotonic component of Aconitum.
Nana, Zhang, Zeqin, Lian, Xueying, Peng, Zijian, Li, Haibo, Zhu   +4 more
openaire   +2 more sources

Blood‐to‐muscle distribution and urinary excretion of higenamine in rats

Drug Testing and Analysis, 2021
AbstractHigenamine is a β2‐agonist that has been prohibited in sports by the World Anti‐Doping Agency. Higenamine could potentially promote anabolism and lipolysis; however, its crucial pharmacokinetics data, particularly muscle distribution, remain unavailable.
William Chih‐Wei Chang, Ching‐Chi Yen, Wan‐Yi Liu, Yun‐Shan Hsieh, Mei‐Chich Hsu, Yu‐Tse Wu   +5 more
openaire   +2 more sources

ELISA for the Detection of the Prohibited Doping Agent Higenamine

Planta Medica, 2020
AbstractHigenamine is a natural benzyltetrahydroisoquinoline alkaloid produced by various plants. In the World Anti-Doping Agency report of 2020, higenamine is classified as a class S3 (selective and nonselective β2-agonist) prohibited substance. To minimize the problems resulting from the misuse of higenamine-containing products as well as from the ...
Poomraphie, Nuntawong, Hiroyuki, Tanaka, Seiichi, Sakamoto, Satoshi, Morimoto   +3 more
openaire   +2 more sources

A novel β2-AR agonist, Higenamine, induces β-arrestin-biased signaling

Science China Life Sciences, 2021
The biased ligands in G protein-coupled receptors (GPCRs) have opened new avenues for developing safer and more effective drugs. However, the identification of such biased ligands as drug candidates is highly desirable. Here, we report that Higenamine, a compound isolated from a Chinese herb, functions as a novel β-arrestin-biased ligand of the β2 ...
Nana, Zhang, Haibo, Zhu, Zijian, Li, Erdan, Dong   +3 more
openaire   +2 more sources