A Narrative Review on Higenamine: Pharmacological Properties and Clinical Applications [PDF]
NutrientsBackground: Higenamine, a bioactive alkaloid derived from plants such as Aconitum and Annona squamosa, has been traditionally used in Chinese medicine for treating heart diseases like bradycardia, arrhythmia, and heart failure. It exhibits multiple pharmacological effects, including anti-oxidative stress, improved cellular energy metabolism, anti ...
Hanghao Shi +9 more
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Pharmacological effects of higenamine based on signalling pathways and mechanism of action [PDF]
Frontiers in Pharmacology, 2022 Higenamine (HG) is a chemical compound found in various plants, such as aconite. Recent pharmacological studies have demonstrated its effectiveness in the management of many diseases.
De-ta Chen +6 more
doaj +4 more sources
β2‐Adrenoceptor agonist activity of higenamine [PDF]
Drug Testing and Analysis, 2021 AbstractHigenamine was included in the World Anti‐Doping Agency (WADA) Prohibited Substances and Methods List as a β2‐adrenoceptor agonist in 2017, thereby resulting in its prohibition both in and out of competition. The present mini review describes the physiology and pharmacology of adrenoceptors, summarizes the literature addressing the mechanism of
Thomas J. Hudzik +2 more
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Higenamine decreased oxidative kidney damage induced by ischemia reperfusion in rats [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019 The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In this study, 24 Sprague Dawley female rats were divided into 3 groups.
Mustafa Can GÜLER +5 more
doaj +6 more sources
Potential health risks of foodborne performance-enhancing drugs in competitive sports [PDF]
Heliyon, 2023 Athletes need to consume a significant amount of energy during prolonged training and in high-intensity competition. It is necessary for them to take nutritional foods that recharge their bodies. However, in sporting events of recent years, both domestic
Maoqiong Wei, Ju'an Wang
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Higenamine inhibits IL-1β-induced inflammation in human nucleus pulposus cells [PDF]
Bioscience Reports, 2019 Abstract Intervertebral disc degeneration (IDD) is a natural progression of the aging process associated with inflammation. Higenamine, a plant-based alkaloid, has been identified to possess various pharmacological properties, including anti-inflammatory activity.
Xiaoliang Bai +3 more
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Influence of racemic higenamine on the sinus node
Experimental and Therapeutic Medicine, 2012 The aim of this study was to explore the mechanism of racemic higenamine in the treatment of sick sinus syndrome (SSS). A total of 40 New Zealand rabbits were randomly divided into normal sinus node and damaged sinus node (SND) groups, and each group was randomly divided into treatment and control groups (n=10).
YU Fengxia, Lingting Kong, SHUJUAN WANG
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Higenamine Reduces Fine-Dust-Induced Matrix Metalloproteinase (MMP)-1 in Human Keratinocytes
Plants, 2023 Environmental pollutants such as fine dust are increasingly linked to premature skin aging. In this study, we investigated the protective effects of higenamine, a natural plant alkaloid, against fine-dust-induced skin aging in human keratinocytes (HaCaT ...
DongHyeon Kim +4 more
doaj +3 more sources
Study on the potential mechanism of the active components in YiYiFuZi powder in homotherapy for hetropathy of coronary heart disease and rheumatoid arthritis [PDF]
Frontiers in Chemistry, 2022 In recent years, the incidence of coronary heart disease and rheumatoid arthritis has been increasing, which has become a common public health problem worldwide.
Yuming Wang +9 more
doaj +2 more sources
Assessing anti-doping knowledge among Taiwanese pharmacists [PDF]
BMC Medical Education, 2023 Background Taiwan’s unique health behaviour, such as extensive exposure to Chinese Herbal Medicine (CHM), has introduced a risk of inadvertent doping among competing athletes.
Yun-Chen Lee +5 more
doaj +2 more sources