Results 51 to 60 of about 436,801 (327)

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice [PDF]

, 2010
Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease ...
Benson, G. Martin, C. Connor, Susan, C. Grimsditch, David, G. Reid, David, Kian Kai, Cheng, L. Griffin, Julian   +5 more
core   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents [PDF]

, 2017
peer-reviewedThe gut hormone glucagon-like peptide (GLP)-1 and its analogues represent a new generation of anti-diabetic drugs, which have also demonstrated propensity to modulate host lipid metabolism.
Cryan, John F., Dinan, Timothy G., Kent, Robert M., Mandal, Rupasri, Murphy, Kiera, O’Connor, Paula M., Patterson, Elaine, Peterson, Veronica L., Ross, R Paul, Ryan, Paul M, Seeley, Randy J., Stack, Helena, STANTON, CATHERINE, Wishart, David S.   +13 more
core   +5 more sources

Association of Inflammatory Cells to High-density Lipoprotein Cholesterol ratio with Acute Pulmonary Embolism [PDF]

, 2023
zhaoji Li, Ruifeng Zhang
openalex   +1 more source

Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over

Arthritis Care &Research, EarlyView.
Objective Reports have linked both high and low serum uric acid (SUA) levels to adverse health outcomes. This study aimed to establish a reference interval for SUA in older adults and assessed its association with clinically relevant outcomes in relatively healthy, community‐dwelling individuals aged ≥70 years old.
Amanda J. Rickard, Cammie Tran, Hans G. Schneider, Flavia M. Cicuttini, Anita E. Wluka, Ego Seeman, Johannes T. Neumann, Md Nazmul Karim, Zhen Zhou, Sultana Monira Hussain, David P. Q. Clark, Daniel Clayton‐Chubb, Andrew M. Tonkin, Lawrence J. Beilin, Robyn L. Woods, John J. McNeil   +15 more
wiley   +1 more source

Association of the Monocyte to HDL-cholesterol Ratio with Idiopathic Pulmonary Arterial Hypertension and Disease Severity

Forbes Tıp Dergisi, 2022
Objective: Idiopathic pulmonary arterial hypertension (IPAH) is a disease characterized by abnormal vascular changes in the pulmonary arteries, leading to elevated pulmonary artery pressure.
Hatice SOLMAZ, Mehmet AKBULUT
doaj   +1 more source

Association of ADRB2 polymorphism with triglyceride levels in Tongans [PDF]

, 2013
BackgroundOur previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic ...
Inaoka Tsukasa, Kimura Ryosuke, Matsumura Yasuhiro, Naka Izumi, Ohashi Jun, 大橋 順   +5 more
core   +1 more source

Adipocyte Modulation of High-Density Lipoprotein Cholesterol [PDF]

Circulation, 2010
Background— Adipose harbors a large depot of free cholesterol. However, a role for adipose in cholesterol lipidation of high-density lipoprotein (HDL) in vivo is not established. We present the first evidence that adipocytes support transfer of cholesterol to HDL in vivo as well as in vitro and ...
YuZhen, Zhang, Fiona C, McGillicuddy, Christine C, Hinkle, Sean, O'Neill, Jane M, Glick, George H, Rothblat, Muredach P, Reilly   +6 more
openaire   +2 more sources

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source