Results 191 to 200 of about 4,092,880 (310)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

High-Dimensional Graphical Model Search with the gRapHD R Package

This paper presents the R package gRapHD for efficient selection of high-dimensional undirected graphical models. The package provides tools for selecting trees, forests, and decomposable models minimizing information criteria such as AIC or BIC, and for
Rodrigo Labouriau, David Edwards, Gabriel C. G. Abreu   +2 more
core  

Deep autoencoder for low dimensionality for high dimensional data in regression models and direct inverse analysis of models. [PDF]

Anal Sci
Kaneko H.
europepmc   +1 more source

Knockoff procedure for false discovery rate control in high-dimensional data streams. [PDF]

J Appl Stat, 2023
Wai Tsang K, Tsung F, Xu Z.
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Analyzing Three-Dimensional Panel Data of Forecasts [PDF]

With the proliferation of quality multi-dimensional surveys, it becomes increasingly important for researchers to employ an econometric framework in which these data can be properly analyzed and put to their maximum use.
Kajal Lahiri, Xuguang Sheng, Antony Davies   +2 more
core  

Ensemble learning for predicting birth trauma using high-dimensional data in the neonatal intensive care unit. [PDF]

Sci Rep
Odhiambo CO, Parikh N, Kopec G, Cross AR.   +3 more
europepmc   +1 more source

An Ensemble Outlier Detection Method Based on Information Entropy-Weighted Subspaces for High-Dimensional Data. [PDF]

Entropy (Basel), 2023
Li Z, Zhang L.
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

A Regularized MANOVA Test for Semicontinuous High-Dimensional Data. [PDF]

Biom J
Sabbioni E, Agostinelli C, Farcomeni A.
europepmc   +1 more source