Results 51 to 60 of about 1,077,907 (260)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A network approach for low dimensional signatures from high throughput data
Scientific Reports, 2022 One of the main objectives of high-throughput genomics studies is to obtain a low-dimensional set of observables—a signature—for sample classification purposes (diagnosis, prognosis, stratification).
Nico Curti +4 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
K-means clustering based filter feature selection on high dimensional data
IJAIN (International Journal of Advances in Intelligent Informatics), 2016 With hundreds or thousands of features in high dimensional data, computational workload is challenging. In classification process, features which do not contribute significantly to prediction of classes, add to the computational workload.
Dewi Pramudi Ismi +2 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Guided quantum compression for high dimensional data classification
Machine Learning: Science and TechnologyQuantum machine learning provides a fundamentally different approach to analyzing data. However, many interesting datasets are too complex for currently available quantum computers.
Vasilis Belis +5 more
doaj +1 more source
SLSB-forest:approximate k nearest neighbors searching on high dimensional data
Dianxin kexue, 2017 The study of approximate k nearest neighbors query has attracted broad attention.Local sensitive hash is one of the mainstream ways to solve this problem.Local sensitive hash and its varients have noted the following problems:the uneven distribution of ...
Tu QIAN +3 more
doaj +2 more sources
Dual Query: Practical Private Query Release for High Dimensional Data
The Journal of Privacy and Confidentiality, 2017 We present a practical, differentially private algorithm for answering a large number of queries on high dimensional datasets. Like all algorithms for this task, ours necessarily has worst-case complexity exponential in the dimension of the data. However,
Marco Gaboardi +4 more
doaj +1 more source